Mediators of Inflammation

Metabolism of the Host and Microbes to Modulate Immunocytes 2021


Publishing date
01 Feb 2022
Status
Closed
Submission deadline
01 Oct 2021

Lead Editor

1Chinese Academy of Sciences, Changsha, China

2Yale University, New Haven, USA

3Kansas State University, Manhattan, USA

4Zhejiang University, Hangzhou, China

5China Agricultural University, Beijing, China

6Yangzhou University, Yangzhou, China

This issue is now closed for submissions.
More articles will be published in the near future.

Metabolism of the Host and Microbes to Modulate Immunocytes 2021

This issue is now closed for submissions.
More articles will be published in the near future.

Description

The innate immune system is composed of various innate immune cells, which can sense, eliminate, or adapt to intra-/extracellular threats (e.g., pathogens). Thus, the fine-tuning of innate immune responses is essential for protecting the host from pathogen infection. Indeed, there are many regulators that govern innate immune responses, including metabolic regulators.

Immune cells require copious energy, metabolic intermediates, and even microbial metabolites to support biosynthesis, thus completing the proliferation, development, differentiation, and execution of physiological functions. The metabolic pattern of activated immune cells is quite different from that of resting cells, and the phenotype and function of activated immune cells are also regulated by metabolism. Additionally, pathogens can also evade the host immune responses by affecting the synthesis of several host metabolic intermediates. Therefore, the concept of metabolic flexibility in the proliferation, development, and maturation of immunocytes, and the response to pathogen infection has quickly become an important paradigm in immune cell biology. Emerging studies focus on innate immune metabolism (e.g., macrophages); however, the impact of pathogens on innate immune metabolism and the cross-talk between metabolic reprogramming and innate immune responses need further exploration.

This Special Issue aims to collate state-of-the-art research focused on the interactions between innate immunocyte biology and metabolism, especially immune responses and metabolic reprogramming during pathogen infection. We are particularly interested in studies that strengthen our understanding of the molecular and biochemical mechanisms of metabolic alterations in infectious diseases. This Special Issue welcomes review and original research articles that allow narrowing of existing gaps in knowledge. Systematic reviews are particularly encouraged.

Potential topics include but are not limited to the following:

  • Metabolic modulation of immunocytes in their proliferation, development, and maturation
  • Metabolic reprogramming of innate immune cells in response to pathogens
  • Cross-talk between innate immune cells and metabolic/epigenetic changes
  • Microbial metabolism in the modulation of immunocytes biology
  • Identification and characterization of potential therapeutic targets for infectious diseases

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 8011988
  • - Research Article

Quercetin Alleviates the Progression of Breast Cancer-Related Depression via Inhibiting the Pyroptosis and Promoting the Immune Response

Qing Zhu | Lei Yang | ... | Ying He
  • Special Issue
  • - Volume 2022
  • - Article ID 2567150
  • - Research Article

Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice

Jin Zhang | Jin Zheng | ... | Yong Guo
  • Special Issue
  • - Volume 2021
  • - Article ID 2979124
  • - Research Article

Mesenchymal Stem Cell-Derived Exosomes Modulate Chondrocyte Glutamine Metabolism to Alleviate Osteoarthritis Progression

Kai Jiang | Ting Jiang | ... | Xinzhan Mao
  • Special Issue
  • - Volume 2021
  • - Article ID 7393029
  • - Research Article

UBC Mediated by SEPT6 Inhibited the Progression of Prostate Cancer

Ruochen Zhang | Yaojing Yang | ... | Yongbao Wei
  • Special Issue
  • - Volume 2021
  • - Article ID 7681252
  • - Research Article

Effect of Garlic Organic Sulfides on Gene Expression Profiling in HepG2 Cells and Its Biological Function Analysis by Ingenuity Pathway Analysis System and Bio-Plex-Based Assays

Chenghao Lv | Caiqiong Wang | ... | Si Qin
  • Special Issue
  • - Volume 2021
  • - Article ID 8481013
  • - Review Article

Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value

Yuanyuan Shao | Xiaofeng Pan | Rong Fu
  • Special Issue
  • - Volume 2021
  • - Article ID 5587428
  • - Research Article

The Correlation between Gut Microbiota and Serum Metabolomic in Elderly Patients with Chronic Heart Failure

Zhenhua Wang | Zhaoling Cai | ... | Guorong Lyu
  • Special Issue
  • - Volume 2021
  • - Article ID 2752265
  • - Research Article

Effects of IQW and IRW on Inflammation and Gut Microbiota in ETEC-Induced Diarrhea

Naiyuan Liu | Lingsi Zhou | ... | Gang Liu
  • Special Issue
  • - Volume 2021
  • - Article ID 8698923
  • - Research Article

The Role of Heart Rate, Body Temperature, and Respiratory Rate in Predicting Anastomotic Leakage following Surgery for Rectal Cancer

Jiajun Luo | Hongxue Wu | ... | Qiang Tong
Mediators of Inflammation
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.