Mediators of Inflammation

Atherosclerosis and Autoimmunity


Status
Published

1Sapienza University of Rome, Rome, Italy

2University of Birmingham, Birmingham, UK

3Azienda Ospedaliera Policlinico di Bari, Bari, Italy

4Univeristy Hospital Center “Shefqet Ndroqi”, Tirana, Albania

5Università di Cagliari, Cagliari, Italy


Atherosclerosis and Autoimmunity

Description

Autoimmune rheumatic diseases (AIRDs) are a group of conditions sharing a high risk of cardiovascular morbidity and mortality, mainly due to premature, accelerated atherosclerosis. In the past years, atherosclerosis has emerged as an inflammatory, immune-mediated disease leading to premature vascular damage. Ever-growing evidence supports an independent role for both humoral and cellular immune responses, together with the involvement of innate immunity, in the development of the atherosclerotic plaque. The contribution of the immune system begins in the earliest and reversible stage of the atherosclerotic process, the endothelial dysfunction. It is not surprising to find premature, accelerated atherosclerosis, not fully explained by an excess of traditional cardiovascular risk factors in patients with AIRDs; rather, traditional and disease-related factors seem to interplay and converge into a proinflammatory and proatherogenic phenotype. The goal of this special issue is to provide evidence and extend the knowledge on (i) the complex relationship between atherosclerosis and immune-mediated diseases and (ii) potential effects of AIRDs treatment on the endothelial function and progression of atherosclerosis.

We invite authors to contribute to this special issue with original research and review articles focusing on the contribution of innate and adoptive immune responses in the endothelial dysfunction and in the progression of atherosclerosis in AIRDs and suggesting a role for therapeutic intervention in the management of cardiovascular comorbidity.

Potential topics include but are not limited to the following:

  • Role of B- and T-cell subpopulations in atherosclerosis
  • Autoantigens and autoantibodies in atherosclerosis
  • Effectors of innate immune response in atherosclerosis and AIRDs
  • Role of cytokines and their blockade in the progression of atherosclerosis in AIRDs
  • Chemokines and vascular damage
  • Cellular and molecular biomarkers of premature atherosclerosis in AIRDs
  • Lipid metabolism in AIRDs
  • Assessment of atherosclerosis in patients with AIRDs
  • Effect of treatment of AIRDs on biomarkers of atherosclerosis

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 6730421
  • - Editorial

Atherosclerosis and Autoimmunity

Francesca Romana Spinelli | Francesca Barone | ... | Matteo Piga
  • Special Issue
  • - Volume 2018
  • - Article ID 3424136
  • - Review Article

Protective Effects of Hydroxychloroquine against Accelerated Atherosclerosis in Systemic Lupus Erythematosus

Alberto Floris | Matteo Piga | ... | Alberto Cauli
  • Special Issue
  • - Volume 2018
  • - Article ID 8237209
  • - Research Article

Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated by Serum Amyloid A

K. Lakota | D. Hrušovar | ... | S. Sodin-Semrl
  • Special Issue
  • - Volume 2018
  • - Article ID 6548715
  • - Research Article

Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study

Gian Luca Erre | Matteo Piga | ... | Giuseppe Passiu
  • Special Issue
  • - Volume 2018
  • - Article ID 3897295
  • - Review Article

Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis

Manuela Di Franco | Bruno Lucchino | ... | Francesca Romana Spinelli
  • Special Issue
  • - Volume 2017
  • - Article ID 3102737
  • - Review Article

Cigarette Smoking and Adipose Tissue: The Emerging Role in Progression of Atherosclerosis

Zhiyan Wang | Di Wang | Yi Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 9632846
  • - Review Article

Protective Effects of Methotrexate against Proatherosclerotic Cytokines: A Review of the Evidence

Arduino A. Mangoni | Angelo Zinellu | ... | Gian Luca Erre
  • Special Issue
  • - Volume 2017
  • - Article ID 3824276
  • - Research Article

Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits

Shoucui Gao | Xiaojing Wang | ... | Enqi Liu
  • Special Issue
  • - Volume 2017
  • - Article ID 1070959
  • - Research Article

Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients

Yachung Jeng | Paik Seong Lim | ... | Tsai-Kun Wu
Mediators of Inflammation
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Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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