Mediators of Inflammation

Inflammatory Mediators in Autoimmunity and Systemic Autoimmune Diseases


Status
Published

Lead Editor

1Oslo University Hospital, Oslo, Norway

2Semmelweis University, Budapest, Hungary

3University of Oslo, Oslo, Norway

4University of Oslo, Oslo, Norway


Inflammatory Mediators in Autoimmunity and Systemic Autoimmune Diseases

Description

The intricate interplay among a variety of immunocompetent cells leads to the development of a proinflammatory cascade, eventually causing autoimmune processes and organ damage. Proinflammatory cytokines, chemokines, and other soluble mediators fuel these autoimmune circuits, leading to cell-activation and proinflammatory cell invasion to tissues.

A finely balanced interplay of pro- and anti-inflammatory processes may either lead to chronic inflammation and potential organ damage or the resolution of the inflammatory cascade. Understanding the immunomodulatory and pathogenic mechanisms that contribute to these conditions can lead to the development of novel diagnostic strategies and future effective therapies in autoimmune diseases.

We invite investigators to contribute original research articles as well as review papers that will stimulate to understand the role of various inflammatory mediators in autoimmune processes, as well as systemic autoimmune diseases. The topic of these articles should encompass basic, molecular mechanisms of inflammation in connection with autoimmune processes, cellular and molecular inflammatory functions, which can aid as biomarkers for diagnostics, as well as targeting of the inflammatory machinery as potential therapeutic interventions. The call especially invites articles describing (1) the pathogenic role of T and B cells, the monocyte/macrophage system, granulocytes, dendritic cells, cytokine, chemokine networks, leukotrienes, prostaglandins, and growth factors in the pathogenesis of autoimmunity; (2) advances in molecular genetics and molecular diagnostics; (3) new insights into proinflammatory processes and defective regulatory functions in the development of systemic autoimmune diseases using animal models; (4) potential treatment modalities in managing autoimmune diseases with a special emphasis on modulating inflammatory processes, for example, anticytokine therapy, small molecules, siRNA, or stem cells.

Potential topics include, but are not limited to:

  • Recent developments in autoimmunity, with special emphasis on inflammatory circuits
  • Advances in genetics in inflammation and autoimmunity
  • Granulocytes, granulocyte subsets in systemic autoimmune diseases
  • Proinflammatory and regulatory T- B- NK-cells DCs in autoimmunity
  • Cytokines controlling immune functions and autoimmunity
  • Studying inflammatory mechanisms in systemic autoimmune diseases, using animal model systems
  • Immunocompetent cell- and cytokine/chemokine-targeting in the treatment of systemic autoimmune diseases

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 878712
  • - Editorial

Inflammatory Mediators in Autoimmunity and Systemic Autoimmune Diseases

Britt Nakken | György Nagy | ... | Peter Szodoray
  • Special Issue
  • - Volume 2015
  • - Article ID 564042
  • - Research Article

The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice

Anak A. S. S. K. Dharmapatni | Melissa D. Cantley | ... | David R. Haynes
  • Special Issue
  • - Volume 2015
  • - Article ID 279393
  • - Research Article

Elevated Serum Levels of Soluble TNF Receptors and Adhesion Molecules Are Associated with Diabetic Retinopathy in Patients with Type-1 Diabetes

Shruti Sharma | Sharad Purohit | ... | Jin-Xiong She
  • Special Issue
  • - Volume 2015
  • - Article ID 952536
  • - Review Article

The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease

Nikolett Marton | Eszter Baricza | ... | György Nagy
  • Special Issue
  • - Volume 2015
  • - Article ID 837250
  • - Review Article

The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis

Samuel García | Carmen Conde
  • Special Issue
  • - Volume 2015
  • - Article ID 493012
  • - Review Article

Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments

Bruno Rafael Ramos de Mattos | Maellin Pereira Gracindo Garcia | ... | Patricia Ucelli Simioni
  • Special Issue
  • - Volume 2015
  • - Article ID 657907
  • - Clinical Study

Systemic Autoimmune, Rheumatic Diseases and Coinciding Psoriasis: Data from a Large Single-Centre Registry and Review of the Literature

Anna Bazsó | Péter Szodoray | ... | Gyula Poór
  • Special Issue
  • - Volume 2015
  • - Article ID 653260
  • - Research Article

Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes

Charlotte Berg Holt | Jakob Appel Østergaard | ... | Troels Krarup Hansen
  • Special Issue
  • - Volume 2015
  • - Article ID 785705
  • - Research Article

Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome

Hanna Przepiera-Będzak | Katarzyna Fischer | Marek Brzosko
  • Special Issue
  • - Volume 2015
  • - Article ID 740357
  • - Research Article

Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis

Lucie Andrés Cerezo | Markéta Kuklová | ... | Ladislav Šenolt
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.400
Journal Citation Indicator0.610
Impact Factor4.711
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