Obesity is a chronic metabolic condition with important public health implications. It is associated with a high risk of cardiovascular disease, insulin resistance, hypertension, and other comorbidities. Several authors have suggested that inflammation may be the link among obesity, type 2 diabetes, cardiovascular disease, and abnormalities of innate and adaptive immune function. Indeed, both clinical and experimental observations demonstrate a strong correlation between systemic markers of inflammation and the most serious comorbidities in obesity.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts in defining the role of mediators of inflammation in obesity and related comorbidities. Papers with additional and compelling mechanistic evidence linking the pathogenesis of obesity-related diseases are very welcome.

We are also interested in manuscripts that report the clinical applications of approved or investigational antiobesity drugs with emphasis on efficacy, toxicity, response assessment, multimodality treatment, prognostic factors, and predictive markers.

Potential topics include, but are not limited to:

• Therapeutic instruments targeting obesity and inflammation in humans
• Obesity and inflammation integration of metabolic and immune response
• Obesity, inflammation, and metabolic diseases
• Cross-talk between adipose tissue and immune system
• Adipokines in the immune-stress response: impact of weight loss
• The adipocytes and other cellular mediators in obesity and inflammation
• The role of TLR and NFkB route in obesity and inflammation
• Oxidative stress in obesity and diabetes
• The effect of aging on obesity and inflammatory status
  • Novel inflammation-related adipokines and other adipose tissue-derived inflammatory factors
  • Endoplasmic reticulum stress, hypoxia, and other potential mechanisms underlying inflammation

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: