Mediators of Inflammation

Microglia in Health and Disease: A Double-Edged Sword


Status
Published

1University of Coimbra, Coimbra, Portugal

2University of Beira Interior, Covilhã, Portugal

3Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain


Microglia in Health and Disease: A Double-Edged Sword

Description

The inflammatory response in the central nervous system (CNS), neuroinflammation, may be initiated by a plethora of cues, including infection, traumatic brain injury, toxic metabolites, or autoimmunity. Moreover, neuroinflammation is believed to play an important role in the pathophysiology of brain neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, and epilepsy, and in retinal degenerative diseases like glaucoma and diabetic retinopathy. The hallmark of the neuroinflammatory process is the activation of microglial cells, the resident immune effector cells in the CNS. Microglial cells play an important role in CNS homeostasis during development, adulthood, and ageing. Moreover, its function is tightly regulated by the CNS microenvironment, and increasing evidence suggests that disturbances, such as neurodegeneration and ageing, can have profound consequences for microglial phenotype and function. Depending on the microenvironment, microglia cells may contribute to both damage and repair. In recent years, several groups attempted to explain the potential mechanisms and signaling pathways on the activation of microglial cells on CNS injury, but a lot still remains to be unraveled.

This special issue aims to give an overview of the current research on the role of microglia in health and disease. We invite researchers to contribute with original research as well as review articles on the impact of microglia and microglia reactivity during CNS development and during pathological conditions.

Potential topics include but are not limited to the following:

  • Interplay of microglial cells with other cells (astrocytes, endothelial cells, and neurons)
  • Contribution of microglia reactivity to the development of neurodegenerative diseases
  • Neuroprotective roles of microglial cells
  • Molecular and cellular mechanisms underlying microglia-induced neurotoxicity
  • Neuroprotective strategies against toxicity mediated by neuroinflammation
  • Role of microglia in neurodevelopment
  • Strategies to modulate microglia activity
  • Techniques for imaging neuroinflammation and microglial cells
  • Use of biomarkers to identify activated and resting microglia

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 7034143
  • - Editorial

Microglia in Health and Disease: A Double-Edged Sword

Ana Raquel Santiago | Liliana Bernardino | ... | Joana Gonçalves
  • Special Issue
  • - Volume 2017
  • - Article ID 4316316
  • - Research Article

Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation

Filipa I. Baptista | Célia A. Aveleira | ... | António F. Ambrósio
  • Special Issue
  • - Volume 2017
  • - Article ID 8302636
  • - Research Article

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Dmitri Leonoudakis | Anand Rane | ... | Shankar J. Chinta
  • Special Issue
  • - Volume 2017
  • - Article ID 9383184
  • - Review Article

Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain

Temugin Berta | Jee Eun Lee | Chul-Kyu Park
  • Special Issue
  • - Volume 2017
  • - Article ID 4761081
  • - Review Article

Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases

Maria H. Madeira | Raquel Boia | ... | Ana R. Santiago
  • Special Issue
  • - Volume 2017
  • - Article ID 9478542
  • - Review Article

Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System

Ilse Bollaerts | Jessie Van houcke | ... | Lieve Moons
  • Special Issue
  • - Volume 2017
  • - Article ID 5048616
  • - Review Article

Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases

Lila Carniglia | Delia Ramírez | ... | Mercedes Lasaga
  • Special Issue
  • - Volume 2016
  • - Article ID 2989548
  • - Review Article

M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b

Chiara Parisi | Giulia Napoli | ... | Cinzia Volonté
  • Special Issue
  • - Volume 2016
  • - Article ID 2684098
  • - Research Article

Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice

Ditte Gry Ellman | Matilda Degn | ... | Kate Lykke Lambertsen
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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