Mediators of Inflammation

Cytokines in Autoimmune Disease


Status
Published

1University of Manitoba, Winnipeg, Canada

2Gansu Provincial Hospital, Lanzhou, China

3University of Toronto, Toronto, Canada

4Shandong University, Shandong, China

5University of Oslo, Oslo, Norway


Cytokines in Autoimmune Disease

Description

The incidence and prevalence of autoimmune disease marked increased over the second half of the 20th century, and it has become a major health problem. These diseases are usually chronic and can be life-threating. The causes of autoimmune disease remain largely unknown. The recent advance in knowledge has greatly increased our understanding of pathogenesis of autoimmune disease, and it is widely accepted that environment, gene, and immunity contributed to the development of autoimmunity. Cytokines are a large group of proteins, peptides, and glycoproteins secreted by cells, including chemokines, interleukins, interferons, lymphokines, tumor necrosis factor, growth factors, and adipokines. Cytokines are important players in the pathogenesis of these diseases through multiple ways, such as regulating inflammation and angiogenesis. One of the keys to control autoimmune disease is an improved understanding of cytokines responses in these diseases; such information will aid the development of effective immunotherapeutic agents.

We invite authors to submit original research and review articles that seek to define the roles of cytokines in the pathogenesis and that explore the potential cytokine treatments for autoimmune diseases. We also solicit the submission of case reports and clinical trials relevant to these topics.

Potential topics include but are not limited to the following:

  • Identifying the roles of cytokines in the pathogenesis of autoimmune disease
  • Identifying the effects of cytokines on certain specific cell populations in autoimmune disease
  • Clinical and preclinical evaluation of novel and effective anticytokine strategies for autoimmune disease
  • Clinical and preclinical evaluation of cytokine-based immunotherapeutic strategies to treat autoimmune disease
  • Identifying cytokine based biomarkers, correlated with the severity of autoimmune disease

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 5089815
  • - Editorial

Cytokines in Autoimmune Disease

Qingdong Guan | Xiaoling Gao | ... | Sudhanshu Shekhar
  • Special Issue
  • - Volume 2017
  • - Article ID 1567120
  • - Research Article

IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes

Bing Wang | Zijian Ma | ... | Xia Li
  • Special Issue
  • - Volume 2017
  • - Article ID 4810258
  • - Review Article

Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

Qingdong Guan | Jiguo Zhang
  • Special Issue
  • - Volume 2017
  • - Article ID 2405291
  • - Research Article

Cytokine Imbalance as a Common Mechanism in Both Psoriasis and Rheumatoid Arthritis

Yong Tan | Qiu Qi | ... | Cheng Xiao
  • Special Issue
  • - Volume 2017
  • - Article ID 4639081
  • - Research Article

Gαq Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation

Dashan Wang | Yuan Liu | ... | Guixiu Shi
  • Special Issue
  • - Volume 2017
  • - Article ID 6567432
  • - Research Article

Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis

Beatriz Coutinho de Sousa | Juliana Reis Machado | ... | Carlo José Freire Oliveira
  • Special Issue
  • - Volume 2017
  • - Article ID 1732638
  • - Research Article

Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level

Jinhui Ma | Wanshou Guo | ... | Peng Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 3916395
  • - Review Article

General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD

Chen Xiaoheng | Mei Yizhou | ... | Ding Zhiguo
  • Special Issue
  • - Volume 2016
  • - Article ID 7420127
  • - Research Article

Serum Cytokine Profiles in Children with Crohn’s Disease

Ekaterina Vasilyeva | Sayar Abdulkhakov | ... | Albert Rizvanov
  • Special Issue
  • - Volume 2016
  • - Article ID 7617954
  • - Research Article

Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis

Hanna Przepiera-Będzak | Katarzyna Fischer | Marek Brzosko
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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