Mediators of Inflammation

Immune Response in Critically Ill Patients


Status
Published

Lead Editor

1University of Defence, Belgrade, Serbia

2University of Cambridge, Cambridge, UK


Immune Response in Critically Ill Patients

Description

Critical illness is defined by presence of altered organ function in acutely ill patients such that homeostasis cannot be maintained without medical intervention in intensive care units, such as mechanical ventilation, vasoactive support for hemodynamics, and renal replacement therapy. It usually involves two or more organ systems. Immune dysfunction is common in critically ill patients and it may modulate immune response and affect patient morbidity and mortality, particularly in severe trauma and/or sepsis. Immune cells and mediators, in critical care setting, are understudied and do represent challenging area. Better understanding of potential beneficial and/or harmful effects of pro- and/or anti-inflammatory response will improve process of intensive care. Potential therapeutic interventions may improve clinical outcome. Pro- and anti-inflammatory mediators can be predictive biomarkers of organ dysfunction and outcome in critically ill patients also. The editors are pleased to launch this new special issue.

This special issue is intended to provide platform for discussion of immune cells’ and mediators’ role in immune response in critical illness; their role as predictive biomarkers of organ dysfunction and outcome; and potential therapeutic procedures regarding immune dysfunction in critically ill patients.

We call for papers and review articles or original research articles.

Potential topics include but are not limited to the following:

  • Molecular mechanism of trauma and/or sepsis-induced immunomodulation and immunosuppression in critically ill patients
  • Role of immune cells (polymorphonuclear leukocytes, myeloid-derived suppressor cells, lymphocytes, platelets, endothelial cells, etc.) in critically ill patients. Association of their altered phenotype, function, and activity with clinical signs and symptoms, clinical score, and disease outcome
  • Estimation of immunoinflammatory response in critically ill patients based on biomarkers of infection and sepsis (cytokines, CD64 expression, HLA-DR expression, endotoxin, parameters of oxidative metabolism, etc.)
  • Specific immune dysfunction underlying failure of various organs (lung, liver, kidney, brain, etc.).
  • Immune based therapy of critically ill patients

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 9524315
  • - Editorial

Immune Response in Critically Ill Patients

Maja Surbatovic | Danilo Vojvodic | Wasim Khan
  • Special Issue
  • - Volume 2018
  • - Article ID 3758068
  • - Research Article

Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume-to-Platelet Count Ratio as Biomarkers in Critically Ill and Injured Patients: Which Ratio to Choose to Predict Outcome and Nature of Bacteremia?

Dragan Djordjevic | Goran Rondovic | ... | Danilo Vojvodic
  • Special Issue
  • - Volume 2018
  • - Article ID 5871431
  • - Research Article

Sophocarpine Attenuates LPS-Induced Liver Injury and Improves Survival of Mice through Suppressing Oxidative Stress, Inflammation, and Apoptosis

Zhengyu Jiang | Yan Meng | ... | Xiaoming Deng
  • Special Issue
  • - Volume 2018
  • - Article ID 1752836
  • - Research Article

Reduced NLRP3 Gene Expression Limits the IL-1β Cleavage via Inflammasome in Monocytes from Severely Injured Trauma Patients

Shinwan Kany | Johann-Philipp Horstmann | ... | Borna Relja
  • Special Issue
  • - Volume 2018
  • - Article ID 1942193
  • - Research Article

A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis

Aleksandar R. Zivkovic | Sebastian O. Decker | ... | Thorsten Brenner
  • Special Issue
  • - Volume 2018
  • - Article ID 4065362
  • - Research Article

Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality

Jaimin M. Patel | Elizabeth Sapey | ... | David R. Thickett
  • Special Issue
  • - Volume 2018
  • - Article ID 7028267
  • - Research Article

Selected Biomarkers Correlate with the Origin and Severity of Sepsis

Michal Holub | Olga Džupová | ... | Ondřej Beran
  • Special Issue
  • - Volume 2017
  • - Article ID 8473171
  • - Research Article

Significant Cytokine mRNA Expression Changes Immediately after Initiation of Cardiopulmonary Resuscitation

Mareen Braunstein | Martina Williamson | ... | Viktoria Bogner
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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