Mediators of Inflammation

Inflammation of the Dental Pulp


Lead Editor

1Kyung Hee University, Seoul, Republic of Korea

2Sichuan University, Sichuan, China

3University of Otago, Dunedin, New Zealand

4University of Lyon, Lyon, France

5Tokushima University Hospital, Tokushima, Japan

Inflammation of the Dental Pulp


The dental pulp is sensitive to external factors such as microbial infection from dental caries and/or mechanical/chemical irritations during dental procedures. Dental tissue behaves differently to the other connective tissues. It is unique in a way that its soft tissues (pulp and pulp-dentin complex) are enclosed within mineralized hard tissues (enamel, dentin, and cement), and its pulp is supplied by a rich neurovascular network that regulates various inflammatory mediators. Inflammatory signals may progress to rapid degeneration and necrosis, and such events could inflict very serious damage on tissues in the body. The treatment of dental caries and the tooth abnormalities involves the cleaning and shaping of the enamel and dentin, that is, the hardest tissues in the body, thus aggravates the pulpitis.

Some known causative agents of inflammation in the dental pulp and the root apex are as follows: 1) the ingression of microorganisms through dental caries, crack, or dentinal tubules of the teeth, 2) chemical irritation from etching and/or bonding materials for adhesion of dental materials, 3) mechanical irritation during preparation in restorative procedures, and 4) TFO (trauma from occlusion) or orthodontic movement of the teeth.

Such agents may initiate the inflammatory cascades, which in turn further develop into pain and root resorption via neurogenic inflammation and hard tissue remodeling. Therefore, thorough understanding of the pulpal inflammatory mechanisms, neurogenic inflammation, and hard tissue remodeling by resorption is essential in development of proper dental procedures and immunotherapeutic agents.

We invited authors to submit original research and review articles in order to define pulpal responses to all these variables and also discuss recent advances in our understanding of dental management.

Potential topics include, but are not limited to:

  • The role of microorganisms in inflammation of the dental pulp
  • New antigenic targets of the human immune response to pulpal inflammation
  • New cellular and animal models to test and understand pulpal inflammation
  • Role of neurogenic inflammation in the dental pulp
  • Development of immunotherapeutic strategies for the pulp necrosis
  • Recent advances in anti-inflammatory drugs in the dental pulp
  • Recent advances in antibiotics in the dental pulp
  • Mineralization in the process of pulpal inflammation
  • The process of tooth root resorption during inflammation
  • Role of epigenetic regulators in dental pulp inflammation


  • Special Issue
  • - Volume 2015
  • - Article ID 980196
  • - Editorial

Inflammation of the Dental Pulp

Sang Hyuk Park | Ling Ye | ... | Hiromichi Yumoto
  • Special Issue
  • - Volume 2015
  • - Article ID 409347
  • - Review Article

In Vivo Experiments with Dental Pulp Stem Cells for Pulp-Dentin Complex Regeneration

Sunil Kim | Su-Jung Shin | ... | Euiseong Kim
  • Special Issue
  • - Volume 2015
  • - Article ID 385127
  • - Research Article

The Anti-Inflammatory Effect of Human Telomerase-Derived Peptide on P. gingivalis Lipopolysaccharide-Induced Inflammatory Cytokine Production and Its Mechanism in Human Dental Pulp Cells

Yoo-Jin Ko | Kil-Young Kwon | ... | Won-Jun Shon
  • Special Issue
  • - Volume 2015
  • - Article ID 794143
  • - Review Article

An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp

Ji-Hyun Jang | Hee Woong Shin | ... | Sang Hyuk Park
  • Special Issue
  • - Volume 2015
  • - Article ID 230251
  • - Review Article

Dental Pulp Defence and Repair Mechanisms in Dental Caries

Jean-Christophe Farges | Brigitte Alliot-Licht | ... | Paul R. Cooper
  • Special Issue
  • - Volume 2015
  • - Article ID 879126
  • - Clinical Study

Sensory Neuropeptides and Endogenous Opioids Expression in Human Dental Pulp with Asymptomatic Inflammation: In Vivo Study

Daniel Chavarria-Bolaños | Hector Flores-Reyes | ... | Amaury Pozos-Guillen
  • Special Issue
  • - Volume 2015
  • - Article ID 347649
  • - Review Article

Is Pulp Inflammation a Prerequisite for Pulp Healing and Regeneration?

Michel Goldberg | Akram Njeh | Emel Uzunoglu
Mediators of Inflammation
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