Mediators of Inflammation

Interplay between Oxidative Stress and Inflammation in Cardiometabolic Syndrome


Publishing date
15 Apr 2016
Status
Published
Submission deadline
27 Nov 2015

1University of Adelaide, Adelaide, Australia

2University of Sydney, Sydney, Australia

3Boston University School of Medicine, Boston, USA


Interplay between Oxidative Stress and Inflammation in Cardiometabolic Syndrome

Description

Cardiometabolic syndrome (CMS) is generally defined as the presence of at least 3 of the following interrelated risk factors and disease states that promote the development of atherosclerotic vascular disease and type 2 diabetes mellitus: obesity, as the hallmark component of CMS, insulin resistance, hypertension, and high triglyceride or low HDL plasma levels. In a number of definitions, obesity is a mandatory component with additional 2-3 risk factors required to make a diagnosis of CMS. Clinical importance of CMS is engendered in the fact that while each of the component conditions has an independent effect, their clustering has a synergistic effect above and beyond simple summation, making the risk of developing cardiovascular disease exponentially greater. Obesity with the associated components has a direct effect on atherogenic dyslipidemia, elevated blood pressure, and elevated plasma glucose that promotes proinflammatory and prothrombic states.

Increased oxidative stress has emerged as a major mediator of pathophysiological processes in obesity, CMS, and cardiovascular disease. While cellular oxidases are known sources of reactive oxygen species, mitochondria has now been implicated as a major source of reactive oxygen species, especially in diabetes, obesity, and cardiovascular diseases. Furthermore, oxidative stress-mediated mitochondrial dysfunction has emerged as a potential key mechanism behind a number of cardiovascular diseases.

Low-grade inflammation is a common manifestation in CMS and could play a role in the pathogenesis of obesity and cardiometabolic syndrome and its sequelae. Dysregulation of adipose tissue biology plays a potential role in the initiation of inflammatory events in obesity and CMS causing chronic inflammatory response characterized by abnormal adipokine production and the activation of several proinflammatory signaling pathways, resulting in the induction of several biological markers of inflammation.

We invite original research and review articles focusing on interaction of inflammation and oxidative stress in the setting of CMS.

Potential topics include, but are not limited to:

  • Biomarkers of oxidative stress and inflammation in cardiometabolic syndrome
  • Role of cardiac and adipose tissue mitochondria in pathophysiology of cardiometabolic syndrome or its sequelae
  • Role of inflammation and oxidative stress in adipose tissue as an initiator/mediator of cardiometabolic syndrome
  • Cardiometabolic syndrome and oxidative/proinflammatory signaling

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8254590
  • - Editorial

Interplay between Oxidative Stress and Inflammation in Cardiometabolic Syndrome

Aaron L. Sverdlov | Gemma A. Figtree | ... | Doan T. M. Ngo
  • Special Issue
  • - Volume 2016
  • - Article ID 5613056
  • - Research Article

Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection

Matilde Otero-Losada | Hernán Gómez Llambí | ... | José Milei
  • Special Issue
  • - Volume 2016
  • - Article ID 9754808
  • - Research Article

Platelet Reactivity Is Independent of Left Atrial Wall Deformation in Patients with Atrial Fibrillation

Nathan Procter | Vincent Goh | ... | John Horowitz
  • Special Issue
  • - Volume 2015
  • - Article ID 106237
  • - Research Article

Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans

Shakun Karki | Melissa G. Farb | ... | Noyan Gokce
  • Special Issue
  • - Volume 2015
  • - Article ID 352356
  • - Research Article

Plasma Nitration of High-Density and Low-Density Lipoproteins in Chronic Kidney Disease Patients Receiving Kidney Transplants

Ahmed Bakillah | Fasika Tedla | ... | Clinton Brown
  • Special Issue
  • - Volume 2015
  • - Article ID 620919
  • - Research Article

Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents

Mar Quiñones | Cintia Folgueira | ... | Omar Al-Massadi
  • Special Issue
  • - Volume 2015
  • - Article ID 824589
  • - Research Article

Inflammation, Oxidative Stress, and Antioxidants Contribute to Selected Sleep Quality and Cardiometabolic Health Relationships: A Cross-Sectional Study

Thirumagal Kanagasabai | Chris I. Ardern
  • Special Issue
  • - Volume 2015
  • - Article ID 796562
  • - Research Article

Symmetric Dimethylarginine Is Not Associated with Cumulative Inflammatory Load or Classical Cardiovascular Risk Factors in Rheumatoid Arthritis: A 6-Year Follow-Up Study

Theodoros Dimitroulas | James Hodson | ... | George D. Kitas
  • Special Issue
  • - Volume 2015
  • - Article ID 524291
  • - Research Article

Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men

Sun Min Lee | Young Hye Cho | ... | Junehee Han
  • Special Issue
  • - Volume 2015
  • - Article ID 614357
  • - Research Article

Influence of Malondialdehyde and Matrix Metalloproteinase-9 on Progression of Carotid Atherosclerosis in Chronic Renal Disease with Cardiometabolic Syndrome

Senija Rašić | Damir Rebić | ... | Marina Delić Šarac
Mediators of Inflammation
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Acceptance rate14%
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CiteScore7.700
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