Mediators of Inflammation

Biomarkers in Inflammatory Childhood Diseases

Publishing date
09 Nov 2012
Submission deadline
22 Jun 2012

Lead Editor

1Centre of Molecular and Cellular Intervention and Department of Paediatric Immunology, University Medical Centre Utrecht, Lundlaan 6, 3584EA Utrecht, The Netherlands

2Department of Science, Roosevelt Academy Middelburg, Utrecht University, 4330 AB Middelburg, Laboratory of Medical Microbiology and Immunology, St. Antonius Hospital, P.O. Box 2500, 3430 EM Nieuwegein, The Netherlands

3Department of General Pediatrics, University Children's Hospital Muenster Muenster, Institute of Immunology, University Hospital Muenster, 48147 Muenster, Germany

Biomarkers in Inflammatory Childhood Diseases


A biomarker is a characteristic that is measured and evaluated as an indicator of a normal biologic or pathologic process or pharmacologic responses towards a therapeutic intervention (definition by the NIH). Biomarkers can be detected and measured in parts of the body like the blood, urine, or tissue and can involve specific cells, molecules, genes, gene products, enzymes, or hormones. Biomarkers are of crucial importance in modern medicine for risk assessment and disease prevention, early diagnosis, drug target identification, drug response, and so forth. Although the term biomarker is relatively new, biomarkers have been used for considerable time. For example, body temperature is a well-known biomarker for fever, serum levels of C-reactive protein (the most performed assay in hospital laboratories) are a marker for inflammation, and glucose levels are used as therapeutic readout for controlling diabetes.

Biomarkers for childhood diseases are, due to ethical restrictions, small populations, and limited sample volumes, less available. Mostly they are extrapolated from adult populations or animal models. Insight and progression of complex paediatric diseases, in particular inflammatory diseases, can benefit from establishment and validation of a comprehensive set of biomarkers. For this special issue we take particular interest in manuscripts that describe biomarkers in immune-mediated childhood diseases based on three topics: first methodologies to detect biomarkers in pediatric patients, second sharing new insight for diagnosis and therapeutic interventions, and third translation of known biomarkers to pediatrics. Potential topics include, but are not limited to:

  • Methods for biomarker discovery:
    • Biomarker imaging in pediatrics
    • Cells as biomarkers in pediatrics
    • Proteins as biomarkers in pediatrics
  • Biomarkers for diagnosis and therapeutic interventions:
    • Biomarkers for diagnosis of (rare) pediatric diseases
    • Biomarkers for monitoring therapeutic interventions (e.g. sepsis, viral infections, and autoimmunity)
  • Translation of biomarkers to pediatric patients:
    • Translation of biomarkers from adult disease
    • Translation of biomarkers from (adult) animal models

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2013
  • - Article ID 745493
  • - Editorial

Biomarkers in Inflammatory Childhood Diseases

Wilco de Jager | Dirk Holzinger | Ger T. Rijkers
  • Special Issue
  • - Volume 2013
  • - Article ID 495848
  • - Research Article

IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus Infection

Antonio Chiaretti | Silvia Pulitanò | ... | Riccardo Riccardi
  • Special Issue
  • - Volume 2013
  • - Article ID 345217
  • - Research Article

Evaluation of Clinical and Immunological Responses: A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite

Heleen Moed | Roy Gerth van Wijk | ... | J. C. van der Wouden
  • Special Issue
  • - Volume 2013
  • - Article ID 760691
  • - Clinical Study

Evaluation of Adipokines: Apelin, Visfatin, and Resistin in Children with Atopic Dermatitis

Edyta Machura | Maria Szczepanska | ... | Alicja Kasperska-Zajac
  • Special Issue
  • - Volume 2012
  • - Article ID 143428
  • - Research Article

Circulating Cytokines and Growth Factors in Pediatric Pulmonary Hypertension

Mark Duncan | Brandie D. Wagner | ... | D. Dunbar Ivy
  • Special Issue
  • - Volume 2012
  • - Article ID 162571
  • - Research Article

Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze

E. M. M. Klaassen | K. D. G. van de Kant | ... | E. Dompeling
  • Special Issue
  • - Volume 2012
  • - Article ID 948367
  • - Review Article

Update of Faecal Markers of Inflammation in Children with Cystic Fibrosis

Jung M. Lee | Steven T. Leach | ... | Chee Y. Ooi
Mediators of Inflammation
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Acceptance to publication29 days
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