Comparison of Perioperative, Functional, and Oncological Outcomes of Transperitoneal and Extraperitoneal Laparoscopic Radical Prostatectomy

Table 6

Cox univariable and multivariable analyses.

Variable	Univariable analysis			Multivariable analysis
	HR	95% Cl	value	HR	95% Cl	value
Age (years)
<70	Ref		0.083			0.018
≥70	1.45	0.95, 2.2		1.71	1.1, 2.68
Clinical T stage
T1-T2b	Ref		<0.001			<0.001
T2c	0.77	0.34, 1.74		0.53	0.22, 1.27
T3a	1.6	0.62, 4.12		0.95	0.33, 2.72
T3b-T4	4.01	1.78, 9.05		1.82	0.65, 5.06
Initial PSA (ng/mL)
≤10	Ref		<0.001	Ref		0.609
10–20	1.4	0.79, 2.48		1.24	0.69, 2.26
>20	2.62	1.55, 4.46		1.36	0.73, 2.55
Gleason grade group
1	Ref		<0.001
2	1.65	0.84, 3.25
3	2.91	1.53, 5.53
4	4.58	2, 10.48
5	8.33	4.25, 16.33
BMI (mg/m ^2 )
<25	Ref		0.313
≥25	1.24	0.82, 1.89
NCCN risk classification
Low	Ref		<0.001
Intermediate	0.81	0.24, 2.7
High	1.62	0.49, 5.37
Very high	5.64	1.73, 18.32
Margin status
Negative	Ref		<0.001	Ref		0.046
Positive	2.76	1.78–3.85		1.52	1.01–2.29
LVI status
Negative	Ref		<0.001
Positive	2.33	1.45, 3.73
Pathologic Gleason score
6	Ref		<0.001			0.021
7	1.64	0.92, 2.91		1.39	0.74, 2.61
≥8	5.17	2.81, 9.5		2.71	1.28, 5.74
pT stage
1-2c	Ref		<0.001	Ref		<0.001
3a	1.93	0.99, 3.78		2.78	1.6–4.83
3b-4	5.83	3.7, 9.18		5.15	3.07–8.64
pN stage
0	Ref		0.006	Ref		0.028
1	3.06	1.53, 6.12		3.1	1.65–5.81
Technique
Intraperitoneal	Ref
Transperitoneal	1.12	0.7, 1.79	0.638

BMI; body mass index, NCCN; National Comprehensive Cancer Network, and LVI; lymphovascular invasion.