Optimal Tolerance Design and Optimization for a Pharmaceutical Quality Characteristic

Table 3

ANOVA of the mean of 𝑦 (𝜇_𝑦).

Predictor	Coef	SE Coef	𝑇		𝑃
Constant	8.0877	0.4857	16.65		0.000
𝑥1	0.6315	0.3222	1.96		0.078
𝑥2	0.7573	0.3222	2.35		0.041
𝑥3	0.7236	0.3222	2.25		0.049
𝑥1𝑥2	−0.7259	0.4210	−1.72		0.115
𝑥1𝑥3	2.1314	0.4210	5.06		0.000
𝑥2𝑥3	0.3984	0.4210	0.95		0.366
𝑥1𝑥1	−0.3435	0.3136	−1.10		0.299
𝑥2𝑥2	0.5507	0.3136	1.76		0.110
𝑥3𝑥3	−0.9727	0.3136	−3.10		0.011
𝑆=1.1908	𝑅^2 = 85.5%		𝑅^2 (adj) = 72.4%
Analysis of variance
Source	DF	SS	MS	𝐹	𝑃
Regression	9	83.371	9.263	6.53	0.004
Residual error	10	14.18	1.418
Total	19	97.55