Optimal Tolerance Design and Optimization for a Pharmaceutical Quality Characteristic

Table 4

ANOVA of the variance of y (𝜎²_𝑦).

Predictor	Coef	SE Coef	𝑇		𝑃
Constant	0.4944	0.0225	21.92		0.000
𝑥1	0.0219	0.0149	1.46		0.174
𝑥2	0.0343	0.0149	2.30		0.044
𝑥3	0.0237	0.0149	1.58		0.144
𝑥1𝑥2	−0.0327	0.0195	−1.67		0.125
𝑥1𝑥3	0.0755	0.0195	3.86		0.003
𝑥2𝑥3	0.0157	0.0195	0.81		0.439
𝑥1𝑥1	−0.0110	0.0145	−0.76		0.465
𝑥2𝑥2	0.0246	0.0145	1.69		0.122
𝑥3𝑥3	−0.0366	0.0145	−2.52		0.030
𝑆=0.0553138	𝑅^2 = 79.6%		𝑅^2 (adj) = 61.2%
Analysis of variance
Source	DF	SS	MS	𝐹	𝑃
Regression	9	0.119074	0.01323	4.32	0.016
Residual error	10	0.030596	0.00306
Total	19	0.149671