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Mathematical Problems in Engineering
Volume 2015 (2015), Article ID 275831, 12 pages
Review Article

On Feature Selection and Rule Extraction for High Dimensional Data: A Case of Diffuse Large B-Cell Lymphomas Microarrays Classification

1Department of Electrical Engineering, Faculty of Engineering, Chiang Mai University, Chiang Mai 50200, Thailand
2Biomedical Engineering Center, Chiang Mai University, Chiang Mai 50200, Thailand
3Department of Computer Engineering, Faculty of Engineering, Chiang Mai University, Chiang Mai 50200, Thailand

Received 28 April 2015; Accepted 13 September 2015

Academic Editor: Chunlin Chen

Copyright © 2015 Narissara Eiamkanitchat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Neurofuzzy methods capable of selecting a handful of useful features are very useful in analysis of high dimensional datasets. A neurofuzzy classification scheme that can create proper linguistic features and simultaneously select informative features for a high dimensional dataset is presented and applied to the diffuse large B-cell lymphomas (DLBCL) microarray classification problem. The classification scheme is the combination of embedded linguistic feature creation and tuning algorithm, feature selection, and rule-based classification in one neural network framework. The adjustable linguistic features are embedded in the network structure via fuzzy membership functions. The network performs the classification task on the high dimensional DLBCL microarray dataset either by the direct calculation or by the rule-based approach. The 10-fold cross validation is applied to ensure the validity of the results. Very good results from both direct calculation and logical rules are achieved. The results show that the network can select a small set of informative features in this high dimensional dataset. By a comparison to other previously proposed methods, our method yields better classification performance.