Research Article
Prediction of “Aggregation-Prone” Peptides with Hybrid Classification Approach
Table 5
The performance comparison of Aggre_Easy and Aggre_Balance with existing 12 predictors.
| Method | Sn (%) | Sp (%) | (%) | MCC | TP | TN | FP | FN |
| Aggrescan | 35.37 | 79.26 | 57.32 | 0.13 | 445 | 5210 | 1363 | 813 | AmyloidMutants | 41.65 | 74.91 | 58.28 | 0.14 | 524 | 4924 | 1649 | 734 | Amyloidogenic Pattern | 13.99 | 94.95 | 54.22 | 0.12 | 176 | 6208 | 365 | 1082 | Average Packing Density | 28.70 | 84.12 | 56.41 | 0.12 | 361 | 5529 | 1044 | 897 | Beta-strand contiguity | 33.15 | 85.62 | 59.39 | 0.18 | 417 | 5628 | 945 | 841 | Hexapeptide Conf. Energy | 39.27 | 78.69 | 58.98 | 0.15 | 494 | 5172 | 1401 | 764 | NetCSSP | 51.27 | 65.22 | 58.25 | 0.12 | 645 | 4287 | 2286 | 613 | PaFigure | 51.75 | 71.43 | 61.59 | 0.18 | 651 | 4695 | 1878 | 607 | SecStr | 11.37 | 94.40 | 52.88 | 0.09 | 143 | 6205 | 368 | 1115 | Tango | 13.67 | 95.57 | 54.62 | 0.14 | 172 | 6282 | 291 | 1086 | Waltz | 56.44 | 65.42 | 60.93 | 0.16 | 710 | 4300 | 2273 | 548 | AMYLPRED | 32.99 | 86.23 | 59.61 | 0.19 | 415 | 5668 | 905 | 843 |
AMYLPRED2 | 39.27 | 84.48 | 61.88 | 0.22 | 494 | 5553 | 1020 | 764 | Aggre_Easy | 79.46 | 74.43 | 76.95 | 0.42 | 1000 | 4892 | 1681 | 258 | Aggre_Balance | 70.32 | 80.70 | 75.51 | 0.42 | 885 | 5304 | 1269 | 373 |
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