Efficient Data Mining Algorithms for Screening Potential Proteins of Drug Target

Algorithm 2

EM for negative Selection Algorithm.

Input: The unlabeled dataset , the positive dataset , the number of selection

Initialization the reliable negative set RN = NULL

Run EM on mixture model using U and P to derive the mixture probability distributions

For each sample in U:

  Compute the probability of the sample assigned as the negative

Rank the above probability likelihood in decreasing order

Select the top L samples to append the RN

Output: The reliable negative samples RN