Practical Identifiability Analysis and Optimal Experimental Design for the Parameter Estimation of the ASM2d-Based EBPR Anaerobic Submodel

<div>Data and residuals of measurement of <svg height="11.8174pt" id="M81" style="vertical-align:-3.1815pt" version="1.1" viewbox="-0.0498162 -8.6359 13.1859 11.8174" width="13.1859pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M449 634C442 637 425 643 405 650C376 660 341 666 307 666C181 666 98 590 98 485C98 400 170 343 215 310L246 288C307 243 343 204 343 147C343 67 291 18 219 18C104 18 61 124 51 202L23 199C28 124 27 71 27 47C47 22 122 -16 204 -16C324 -16 428 60 428 174C428 256 379 309 307 360L276 382C223 419 179 455 179 516C179 576 221 632 293 632C379 632 410 564 418 487L448 490C446 536 446 592 449 634Z" id="g113-84"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.071,3.132)"><path d="M722 32C646 41 636 48 622 116L544 496L509 667L472 658L153 123C106 45 93 42 27 32L18 0H259L268 32C178 40 172 48 204 107L272 233H509C523 180 533 137 540 96C548 50 546 39 466 32L457 0H714L722 32ZM502 283H299L448 547H450L502 283Z" id="g50-66"></path></g></svg> and <span class="nowrap"><svg height="11.9316pt" id="M82" style="vertical-align:-3.2957pt" version="1.1" viewbox="-0.0498162 -8.6359 23.2882 11.9316" width="23.2882pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M449 634C442 637 425 643 405 650C376 660 341 666 307 666C181 666 98 590 98 485C98 400 170 343 215 310L246 288C307 243 343 204 343 147C343 67 291 18 219 18C104 18 61 124 51 202L23 199C28 124 27 71 27 47C47 22 122 -16 204 -16C324 -16 428 60 428 174C428 256 379 309 307 360L276 382C223 419 179 455 179 516C179 576 221 632 293 632C379 632 410 564 418 487L448 490C446 536 446 592 449 634Z" id="g113-84"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.071,3.132)"><path d="M46 650V618C122 613 130 611 130 522V128C130 46 123 40 40 32V0H319V32C227 40 217 42 217 128V279L292 260C303 259 322 258 338 261C436 272 534 337 534 467C534 534 508 580 469 609C428 640 371 650 299 650H46ZM217 558C217 585 220 596 228 603C235 610 256 615 284 615C367 615 435 571 435 463C435 339 358 304 291 304C256 304 229 310 217 317V558Z" id="g58-78"></path></g><g transform="matrix(.0091,0,0,-0.0091,11.285,3.132)"><path d="M387 665C175 665 46 498 46 318C46 123 194 -15 374 -15C558 -15 712 114 712 333C712 535 557 665 387 665ZM364 625C495 625 607 518 607 306C607 115 505 25 396 25C256 25 151 161 151 346C151 532 255 625 364 625Z" id="g58-77"></path></g><g transform="matrix(.0091,0,0,-0.0091,18.174,3.132)"><path d="M462 177V227H365V632H320C217 496 116 350 21 208V177H284V109C284 43 280 38 190 31V0H451V31C369 38 365 43 365 108V177H462ZM284 227H88C155 336 218 430 282 519H284V227Z" id="g50-53"></path></g></svg>.</span></div>

Mathematical Problems in Engineering

fig2

Figure 2

Figure 2: Practical Identifiability Analysis and Optimal Experimental Design for the Parameter Estimation of the ASM2d-Based EBPR Anaerobic Submodel 