Occurrence of pfatpase6 Single Nucleotide Polymorphisms Associated with Artemisinin Resistance among Field Isolates of Plasmodium falciparum in North-Eastern Tanzania

Table 2

Trends of pfatpase6 mutation frequencies from 2010 to 2013 expressed as /154 (%).

SNP	Pfatpase6 genotype	2010	2011	2013	Overall frequency
L263E	Wild type	154 (100)	148 (96.1)	150 (97.4)	145 (94.2)
	Heterozygous	0 (0)	0 (0)	0 (0)	2 (1.3)
	Mutant	0 (0)	6 (3.9)	4 (2.6)	8 (5.2)
	H M	0 (0)	6 (3.9)	4 (2.6)	9 (5.8)
E431K	Wild type	128 (83.1)	138 (89.6)	134 (87.0)	125 (81.2)
	Heterozygous	9 (5.8)	6 (3.9)	4 (2.6)	8 (5.2)
	Mutant	18 (11.7)	11 (7.1)	16 (10.4)	17 (11.0)
	H M	26 (16.9)	16 (10.4)	20 (13.0)	25 (16.2)
A623E	Wild type	154 (100)	154 (100)	154 (100)	154 (100)
	Heterozygous	0 (0)	0 (0)	0 (0)	0 (0)
	Mutant	0 (0)	0 (0)	0 (0)	0 (0)
	H M	0 (0)	0 (0)	0 (0)	0 (0)
S769N	Wild type	150 (97.4)	148 (96.1)	146 (94.8)	148 (96.1)
	Heterozygous	2 (1.3)	0 (0)	0 (0)	1
	Mutant	2 (1.3)	6 (3.9)	8 (5.2)	5 (3.2)
	H M	3 (1.9)	6 (3.9)	8 (5.2)	6 (3.9)

H M: mutant and heterozygous genotype frequencies combined.