Phosphorylated Neurofilament Heavy Chain Correlations to Visual Function, Optical Coherence Tomography, and Treatment

Table 5

Correlations of clinical profile to OCT and pNF-H.

Measurement	Visit	Statistic	Study eye RNFL thickness	Study eye total macular volume	Square root pNFH
EDSS	Year 5	r	−0.28	−0.28	0.15
		P-value	.048	.057	.291
		N	50	47	50
	Year 10	r	−0.38	−0.11	0.02
		P-value	.008	.473	.901
		N	49	46	49
	Year 15	r	−0.23	0.07	0.03
		P-value	.107	.641	.841
		N	51	48	51
LogMAR study eye acuity	Baseline	r	−0.09	−0.29	0.44
		P-value	.512	.046	.001
		N	51	48	51
	Month 1	r	−0.44	−0.41	0.13
		P-value	.002	.005	.364
		N	48	45	48
	Month 6	r	−0.35	−0.22	−0.11
		P-value	.011	.132	.442
		N	51	48	51
	Year 5	r	−0.27	−0.26	−0.18
		P-value	.060	.074	.206
		N	51	48	51
	Year 10	r	−0.52	−0.30	−0.08
		P-value	<.001	.040	.565
		N	50	47	50
	Year 15	r	−0.48	−0.36	0.00
		P-value	<.001	.011	.974
		N	51	48	51
Sensitivity study eye contrast	Baseline	r	0.18	0.23	−0.37
		P-value	.207	.121	.007
		N	51	48	51
	Month 1	r	0.54	0.42	−0.17
		P-value	<.001	.004	.256
		N	48	45	48
	Month 6	r	0.54	0.44	−0.12
		P-value	<.001	.002	.419
		N	51	48	51
	Year 5	r	0.45	0.37	−0.04
		P-value	.001	.010	.759
		N	50	47	50
	Year 10	r	0.52	0.43	0.01
		P-value	<.001	.003	.964
		N	49	46	49
	Year 15	r	0.58	0.52	−0.06
		P-value	<.001	<.001	.685
		N	51	48	51
Study eye visual field mean deviation	Baseline	r	0.24	0.30	−0.29
		P-value	.095	.036	.038
		N	51	48	51
	Month 1	r	0.56	0.46	−0.11
		P-value	<.001	.001	.462
		N	48	45	48
	Month 6	r	0.55	0.34	0.08
		P-value	<.001	.019	.593
		N	51	48	51
	Year 5	r	0.48	0.32	0.06
		P-value	<.001	.029	.650
		N	51	48	51
	Year 10	r	0.57	0.40	0.10
		P-value	<.001	.006	.512
		N	50	47	50
	Year 15	r	0.55	0.30	0.05
		P-value	<.001	.041	.730
		N	51	48	51