CCR5Δ32 Polymorphism Associated with a Slower Rate Disease Progression in a Cohort of RR-MS Sicilian Patients

Table 2

Association between CCR5Δ32 allele and EDSS scores and between CCR5Δ32 allele and age onset.

EDSS at time of examination

Genotype Δ32/+; (sex as covariate)

Genotype Δ32/+; (age as covariate)

Genotype Δ32/+; (age of onset as covariate)

Genotype Δ32/+

Mean ± SD

𝑡

𝑃-value

EDSS

𝐹

𝑑𝑓

𝑃-value

EDSS

𝐹

𝑑𝑓

𝑃-value

EDSS

𝐹

𝑑𝑓

𝑃-value

Age of onset

𝑡

𝑃-value

WT

2.74 ± 1.31

2.04

.04

4.54

1.114

.03

5.12

1.114

.02

5.25

1.114

.02

(−)0.27

.78

Δ32/+

2.00 ± 1.26

Statistical analysis for association between Δ32 allele and EDSS scores was tested by Student's 𝑡-test and ANOVA methods.
MS: multiple sclerosis; EDSS: expanded disability status scale; 𝑃<.05 indicates statistical significance.
Statistical analysis for association between CCR5Δ32 allele and age onset was tested by Student's 𝑡-test. Age of onset was defined by the age at first manifestation of disease; 𝑃<.05 indicates statistical significance.