CCR5Δ32 Polymorphism Associated with a Slower Rate Disease Progression in a Cohort of RR-MS Sicilian Patients

Table 3

Overview of major association studies.

Patients country	Clinical variable	Statistical method	Results	References
Iran	MS development	ANOVA	Yes (predisposing factor)	[29]
Brazil	Age of onset; EDSS	ANOVA; chi-square test; Mann-Whitney U-test	Potential favorable prognostic biomarker	[25]
Denmark	EDSS	Mann-Whitney U-test	No associations	[30]
Spain	Etiopathogeny of the disease	Not available	Yes (protective role)	[31]
Croatia; Slovenia	Age of disease onset or progression of the disease	Not available	No associations	[23]
USA	Age of onset; EDSS	Student’s 𝑡-test; ANOVA	No associations	[22]
Northern Ireland	Age of onset; susceptibility to develop MS	Not available	No associations	[24]
Finland	Susceptibility to develop MS	chi-square test; ANOVA	No associations	[32]
Israel	EDSS	Not available	Potential favorable prognostic biomarker	[20]
Germany	Susceptibility to develop MS	ANOVA	No associations	[33]
USA	Age of onset	Not available	Age of onset was approximately 3 years later in patients carrying the CCR5Δ32 deletion	[19]
Denmark	Susceptibility to develop MS	ANOVA; Student's 𝑡-test	Lower risk	[21]