Serum Metabolic Profile in Multiple Sclerosis Patients

Table 2

Concentration of circulating creatinine, pyrimidine (β-pseudouridine and uridine), oxypurines (hypoxanthine, xanthine and uric acid) malondialdehyde (MDA), nitrite and nitrate (NO₂ + NO₃), and ascorbic acid determined by HPLC in serum samples of healthy controls and MS patients.

	Controls (𝑛=163)	MS patients (𝑛=170)
Creatinine	56.87 ± 17.98	71.10 ± 19.27^a
Uracile	1.97 ± 0.90	2.11 ± 1.04
β-pseudouridine	3.03 ± 1.24	4.67 ± 1.71^a
Uridine	4.83 ± 2.19	7.20 ± 1.82^a
Hypoxanthine	4.19 ± 1.58	12.30 ± 4.84^a
Xanthine	1.44 ± 0.96	4.03 ± 2.20^a
Uric acid	258.08 ± 50.39	299.88 ± 70.17^a
MDA	0.005 ± 0.004	0.84 ± 0.54^a
NO2 + NO3	69.06 ± 29.04	107.94 ± 43.87^a
Ascorbic acid	57.52 ± 14.81	37.36 ± 10.95^a

Values are means ± standard deviations and are expressed in μmol/L serum.
^asignificantly different from controls (𝑃<.001).