The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis

Table 2

Patient characteristics: MS patients diagnosed with depression but untreated compared to MS patients diagnosed with depression who received an antidepressant.

Characteristic	Dx Depression (𝑁=38)		Dx & Rx Depression (𝑁=38)		𝜒^2 statistic	𝑃 value
	𝑁	%	𝑁	%
Characteristics matched on
Age					N/A	N/A
<35	1	2.63	1	2.63
35–44	8	21.04	8	21.04
45–54	19	50.00	19	50.00
55–64	10	26.32	10	26.32
65+	0	0	0	0
Sex					N/A	N/A
Male	2	5.26	2	5.26
Female	36	94.74	36	94.74
Region					N/A	N/A
Northeast	3	7.89	3	7.89
North Central	13	34.21	13	34.21
South	12	31.58	12	31.58
West	10	26.32	10	26.32
Unknown	0	0	0	0
Year of index date					N/A	N/A
2004	6	15.79	6	15.79
2005	11	28.95	11	28.95
2006	10	26.32	10	26.32
2007	10	26.32	10	26.32
2008	1	2.63	1	2.63
ITT DMT					N/A	N/A
Avonex	12	31.58	12	31.58
Betaseron	2	5.26	2	5.26
Copaxone	19	50.00	19	50.00
Rebif	4	10.53	4	10.53
Tysabri	1	2.63	1	2.63
Other characteristics
Insurance status
Comprehensive	6	15.79	4	13.16	0.11	0.744
Health maintenance org	5	13.16	9	23.68	1.40	0.236
Point-of-service	6	15.79	7	18.42	0.93	0.761
Preferred provider org	20	52.63	16	42.11	0.84	0.358
Other	1	2.63	1	2.63	N/A	N/A
Copayment with ITT drug	29	76.32	29	76.32	N/A	N/A
Mail order for ITT drug	13	34.21	10	26.32	0.56	0.454
Preperiod Charlson score
0	23	60.53	21	55.26	0.22	0.642
1-2	11	28.95	15	39.47	0.93	0.334
3+	4	10.53	2	5.26	0.72	0.395
Preperiod disability proxies
Muscoloskeletal	25	65.79	24	63.16	0.06	0.811
Medical	16	42.11	18	47.37	0.22	0.645