Exploring the Association between Retinal Nerve Fiber Layer Thickness and Initial Magnetic Resonance Imaging Findings in Patients with Acute Optic Neuritis

Table 3

Comparing MRI status, corticosteroid therapy, and RNFL* values in nonaffected eyes.

RNFL Non-ON Eyes*	Year 1		P value	Year 2		P value
	MRI+^§ (𝑛=32)	MRI−^|| (𝑛=18)		MRI+ (𝑛=32)	MRI− (𝑛=18)
Overall (SD)^¶	103.9 (10.5)	102.2 (9.4)	.56	104.1 (12.2)	104.3 (9.9)	.94
Superior	131.1 (15.6)	132.9 (13.0)	.67	134.4 (20.6)	135.3 (13.6)	.87
Inferior	134.0 (16.9)	125.4 (12.7)	.07	131.0 (17.9)	127 (14.9)	.42
Nasal	84.3 (17.0)	80.4 (17.7)	.46	84.0 (18.0)	84.7 (21.4)	.89
Temporal	66.3 (13.0)	70.0 (10.1)	.30	66.9 (13.6)	70.7 (13.8)	.34
	Steroid^#; (𝑛=25)	Untreated** (𝑛=25)		Steroid (𝑛=25)	Untreated (𝑛=25)
Overall (SD)	103.6 (9.3)	103.0 (11.0)	.84	104.7 (10.5)	103.6 (12.5)	.75
Superior	130.7 (12.4)	132.8 (16.7)	.63	136.0 (14.7)	133.5 (21.4)	.63
Inferior	131.4 (14.2)	130.5 (17.8)	.85	130.2 (17.8)	129.0 (16.2)	.80
Nasal	85.8 (18.6)	80.0 (15.5)	.23	82.8 (19.8)	85.7 (18.6)	.60
Temporal	66.6 (11.2)	68.6 (13.0)	.56	69.7 (13.8)	66.8 (13.7)	.47

*Retinal nerve fiber layer thickness (μm); ^§Abnormal baseline magnetic resonance imaging study [8]; ^|| Normal baseline magnetic resonance imaging study; ^¶Mean overall RNFL value (standard deviation), and mean RNFL values in the superior, inferior, nasal and temporal quadrants; ^# Patients treated with the equivalent of 1000 mg of intravenous methyl-prednisolone for acute management of optic neuritis; **Patients not treated acutely for optic neuritis.