Research Article

Epitope Analysis of Cerebrospinal Fluid IgG in Japanese Multiple Sclerosis Patients Using Phage Display Method

Table 3

Common peptide motifs derived from 3 CSF samples of MS6.

Peptide motifs
(SPxxMH)(DPYQxP)(PYxxYQxP)

1999.12
(Remission)
SPPKMH DPYQVP PYEFYQYP
SPKSMH GPYQDP PYLNYQHP
SPPLMH DPYQLP
SPRNMH
SPVHMH

2000.1
(Relapse)
SPRIDH DPYQLPPYTGYQ
SPPLMH DPYQSLPYAGYQ
DPYQVY
DQYQQP

2000.10 (Remission)SPYHSH DYYQQHPYSPYQLP
SPRNMHDPYQTAPYNLYQTP
SPGNMHDPYQLPTYGAYQLA
PYAHYQPY

EBV componentIYYSPSIMHRPDPYQLPFAAPYQGYQEPP
(EBV VP19)(EBV ZEBRA)(EBV EBNA 6)

Bold-faced letter indicates common peptide motifs.