Multiple Sclerosis International / 2011 / Article / Fig 1

Review Article

Multiple Sclerosis: A Disorder of Altered T-Cell Homeostasis

Figure 1

sjTRECs in controls and patients. (a) Naïve CD4 sjTREC frequencies (sjTRECs/106 naïve CD4 T-cells) decreased significantly with age only in controls ( ). (b) Naïve CD8 sjTREC frequencies decreased with age only in controls ( ). (c) Total naïve CD4 sjTREC numbers decreased exponentially with age only in controls ( ). Median sjTRECs were higher in controls than in RRMS ( ) or in PPMS ( ) with a trend towards higher sjTREC numbers in RRMS versus PPMS ( ). (d) Thymic export (naïve CD4 T-cells/day) decreased with age only in controls ( ). Both RRMS ( ) and PPMS patients ( ) had significantly reduced median daily thymic export compared to controls.
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