Multiple Sclerosis: A Disorder of Altered T-Cell Homeostasis
sjTRECs in controls and patients. (a) Naïve CD4 sjTREC frequencies (sjTRECs/106 naïve CD4 T-cells) decreased significantly with age only in controls (). (b) Naïve CD8 sjTREC frequencies decreased with age only in controls (). (c) Total naïve CD4 sjTREC numbers decreased exponentially with age only in controls (). Median sjTRECs were higher in controls than in RRMS () or in PPMS () with a trend towards higher sjTREC numbers in RRMS versus PPMS (). (d) Thymic export (naïve CD4 T-cells/day) decreased with age only in controls (). Both RRMS () and PPMS patients () had significantly reduced median daily thymic export compared to controls.