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Multiple Sclerosis International
Volume 2011, Article ID 767083, 18 pages
Review Article

Cerebrospinal Fluid and Blood Biomarkers of Neuroaxonal Damage in Multiple Sclerosis

Neurology Clinic, Clinical Center of Serbia, Dr Subotica 6, P.O. Box 12, 11129 Belgrade 102, Serbia

Received 20 December 2010; Accepted 8 February 2011

Academic Editor: Robert Weissert

Copyright © 2011 Irena Dujmovic. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Following emerging evidence that neurodegenerative processes in multiple sclerosis (MS) are present from its early stages, an intensive scientific interest has been directed to biomarkers of neuro-axonal damage in body fluids of MS patients. Recent research has introduced new candidate biomarkers but also elucidated pathogenetic and clinical relevance of the well-known ones. This paper reviews the existing data on blood and cerebrospinal fluid biomarkers of neuroaxonal damage in MS and highlights their relation to clinical parameters, as well as their potential predictive value to estimate future disease course, disability, and treatment response. Strategies for future research in this field are suggested.