Blood and CSF Biomarker Dynamics in Multiple Sclerosis: Implications for Data Interpretation

Table 1

Patient characteristics at baseline. The median (range) is shown.

Characteristic	PPMS	SPMS	RRMS
Number	9	22	20
Age	52 (46–55)	46 (29–65)	40 (27–55)
Gender (female : male)	6 : 3	11 : 11	11 : 9
Disease duration (years)	16 (6–27)	18 (6–35)	8 (4–13)
EDSS	6 (2–8)	6 (4–7)	2 (1–8)
CSF NfHSMI34 (ng/mL)	0.01 (0–0.05)	0.11 (0–0.04)	0.01 (0–0.04)
CSF NfHSMI35 (ng/mL)	0.10 (0.01–0.15)	0.04 (0.01–0.24)	0.08 (0–1.39)
Serum NfHSMI34 (ng/mL)	2.05 (0–3.08)	0.03 (0.19–2.44)	1.56 (0–2.05)
Serum NfHSMI35 (ng/mL)	0 (0–0.49)	0 (0–0.16)	0 (0–0.27)