Blood and CSF Biomarker Dynamics in Multiple Sclerosis: Implications for Data Interpretation

Table 4

Secondary progressive MS. The patients were classified according to the relationship of CSF and blood NfH levels. If the concentration was higher in the CSF compared to the blood, this was indicated by “C > S” and “S ≥ C” otherwise. The data is presented for each of the two NfH phosphoforms quantified (NfH𝑆𝑀𝐼34 and NfH𝑆𝑀𝐼35). ^⋆𝑃<.05.

Characteristic	NfHSMI35		NfHSMI34
	C > S	S ≥ C	C > S	S ≥ C
Number	15	3	11	7
Age	45 (29–55)	57 (32–65)	49 (32–65)	44 (29–50)
Gender (female : male)	6 : 9	3 : 0	7 : 4	2 : 5
Disease duration (years)	16 (6–28)	22 (15–24)	19 (6–28)	16 (7–22)
EDSS	5 (1–8)	7 (6–8)	6 (3–8)	3 (1–7)
ΔEDSS	0 (−1–3)	0 (−2–0)	0 (−1.5–1.5)	2 (−1–3)⋆