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Multiple Sclerosis International
Volume 2012, Article ID 217802, 5 pages
http://dx.doi.org/10.1155/2012/217802
Clinical Study

The Diagnostic and Prognostic Value of Neurofilament Heavy Chain Levels in Immune-Mediated Optic Neuropathies

1Institute of Neurology, University College London (UCL), London WC1N 3BG, UK
2Department of Neurology, Vrije Universiteit Medisch Centrum (VUMC), Amsterdam, The Netherlands
3The National Hospital for Neurology and Neurosurgery, University College London (UCL), London WC1N 3BG, UK

Received 9 August 2012; Revised 18 November 2012; Accepted 19 November 2012

Academic Editor: Friedemann Paul

Copyright © 2012 Axel Petzold and Gordon T. Plant. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Petzold, “Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss,” Journal of the Neurological Sciences, vol. 233, no. 1-2, pp. 183–198, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Dujmovic, “Cerebrospinal fluid and blood biomarkers of neuroaxonal damage in multiple sclerosis,” Multiple Sclerosis International, vol. 2011, Article ID 767083, 18 pages, 2011. View at Publisher · View at Google Scholar
  3. M. M. Gresle, H. Butzkueven, and G. Shaw, “Neurofilament proteins as body fluid biomarkers of neurodegeneration in multiple sclerosis,” Multiple Sclerosis International, vol. 2011, Article ID 315406, 7 pages, 2011. View at Publisher · View at Google Scholar
  4. A. Petzold, M. M. Tisdall, A. R. Girbes et al., “In vivo monitoring of neuronal loss in traumatic brain injury: a microdialysis study,” Brain, vol. 134, no. 2, pp. 464–483, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Brettschneider, A. Petzold, A. Junker, and H. Tumani, “Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis,” Multiple Sclerosis, vol. 12, no. 2, pp. 143–148, 2006. View at Publisher · View at Google Scholar
  6. I. Miyazawa, I. Nakashima, A. Petzold, K. Fujihara, S. Sato, and Y. Itoyama, “High CSF neurofilament heavy chain levels in neuromyelitis optica,” Neurology, vol. 68, no. 11, pp. 865–867, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Petzold, R. Marignier, M. M. Verbeek, and C. Confavreux, “Glial but not axonal protein biomarkers as a new supportive diagnostic criteria for Devic neuromyelitis optica? Preliminary results on 188 patients with different neurological diseases,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 82, no. 4, pp. 467–469, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Takano, T. Misu, T. Takahashi, S. Sato, K. Fujihara, and Y. Itoyama, “Astrocytic damage is far more severe than demyelination in NMO: a clinical CSF biomarker study,” Neurology, vol. 75, no. 3, pp. 208–216, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Petzold, K. Rejdak, and G. T. Plant, “Axonal degenaration and inflammation in acute optic neuritis,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 75, no. 8, pp. 1178–1180, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Petzold, M. J. Eikelenboom, G. Keir et al., “Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 76, no. 2, pp. 206–211, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Pasol, W. Feuer, C. Yang, G. Shaw, R. Kardon, and J. Guy, “Phosphorylated neurofilament heavy chain correlations to visual function, optical coherence tomography, and treatment,” Multiple Sclerosis International, vol. 2010, Article ID 542691, 10 pages, 2010. View at Publisher · View at Google Scholar
  12. D. Kidd, B. Burton, G. T. Plant, and E. M. Graham, “Chronic relapsing inflammatory optic neuropathy (CRION),” Brain, vol. 126, no. 2, pp. 276–284, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. D. M. Wingerchuk, V. A. Lennon, C. F. Lucchinetti, S. J. Pittock, and B. G. Weinshenker, “The spectrum of neuromyelitis optica,” The Lancet Neurology, vol. 6, no. 9, pp. 805–815, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. R. W. Beck and R. L. Gal, “Treatment of acute optic neuritis: a summary of findings from the optic neuritis treatment trial,” Archives of Ophthalmology, vol. 126, no. 7, pp. 994–995, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Nakamura, T. Nakazawa, H. Doi et al., “Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 248, no. 12, pp. 1777–1785, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. D. M. Wingerchuk, V. A. Lennon, S. J. Pittock, C. F. Lucchinetti, and B. G. Weinshenker, “Revised diagnostic criteria for neuromyelitis optica,” Neurology, vol. 66, no. 10, pp. 1485–1489, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Petzold, S. Pittock, V. Lennon, C. Maggiore, B. G. Weinshenker, and G. T. Plant, “Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 81, no. 1, pp. 109–111, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Petzold, G. Keir, A. J. E. Green, G. Giovannoni, and E. J. Thompson, “A specific ELISA for measuring neurofilament heavy chain phosphoforms,” Journal of Immunological Methods, vol. 278, no. 1-2, pp. 179–190, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. P. V. A. Lennon, D. M. Wingerchuk, T. J. Kryzer et al., “A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis,” The Lancet, vol. 364, no. 9451, pp. 2106–2112, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. A. J. Green and B. A. C. Cree, “Distinctive retinal nerve fibre layer and vascular changes in neuromyelitis optica following optic neuritis,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 80, no. 9, pp. 1002–1005, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Jarius, J. Frederikson, P. Waters et al., “Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis,” Journal of the Neurological Sciences, vol. 298, no. 1-2, pp. 158–162, 2010. View at Publisher · View at Google Scholar
  22. S. Jarius, F. Aboul-Enein, P. Waters et al., “Antibody to aquaporin-4 in the long-term course of neuromyelitis optica,” Brain, vol. 131, no. 11, pp. 3072–3080, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Rundgren, H. Friberg, T. Cronberg, B. Romner, and A. Petzold, “Serial soluble neurofilament heavy chain in plasma as a marker of brain injury after cardiac arrest,” Critical Care, vol. 16, no. 2, article R45, 2012. View at Publisher · View at Google Scholar
  24. H. A. Jensen, S. Loukogeorgakis, F. Yannopoulos et al., “Remote ischemic preconditioning protects the brain against injury after hypothermic circulatory arrest,” Circulation, vol. 123, no. 7, pp. 714–721, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. K. J. Anderson, S. W. Scheff, K. M. Miller et al., “The phosphorylated axonal form of the neurofilament subunit NF-H (pNF-H) as a blood biomarker of traumatic brain injury,” Journal of Neurotrauma, vol. 25, no. 9, pp. 1079–1085, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Tisdall and A. Petzold, “Comment on ‘chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model’,” Science Translational Medicine, vol. 4, no. 157, article 157le8, 2012. View at Google Scholar
  27. S. B. Lewis, R. A. Wolper, L. Miralia, C. Yang, and G. Shaw, “Detection of phosphorylated NF-H in the cerebrospinal fluid and blood of aneurysmal subarachnoid hemorrhage patients,” Journal of Cerebral Blood Flow and Metabolism, vol. 28, no. 6, pp. 1261–1271, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Sellner, A. Patel, P. Dassan, M. M. Brown, and A. Petzold, “Hyperacute detection of neurofilament heavy chain in serum following stroke: a transient sign,” Neurochemical Research, vol. 36, no. 12, pp. 2287–2291, 2011. View at Publisher · View at Google Scholar
  29. J. Sellner, A. Petzold, S. Sadikovic et al., “The value of the serum neurofilament protein heavy chain as a biomarker for peri-operative brain Injury after carotid endarterectomy,” Neurochemical Research, vol. 34, no. 11, pp. 1969–1974, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. C.-H. Lu, B. Kalmar, A. Malaspina, L. Greensmith, and A. Petzold, “A method to solubilise protein aggregates for immunoassay quantification which overcomes the neurofilament “hook“ effect,” Journal of Neuroscience Methods, vol. 195, no. 2, pp. 143–150, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. K. B. Boylan, J. D. Glass, J. E. Crook et al., “Phosphorylated neurofilament heavy subunit (pNF-H) in peripheral blood and CSF as a potential prognostic biomarker in amyotrophic lateral sclerosis,” 2012, Journal of Neurology, Neurosurgery and Psychiatry. In Press.
  32. L. J. Balcer, M. L. Baier, J. A. Cohen et al., “Contrast letter acuity as a visual component for the multiple sclerosis functional composite,” Neurology, vol. 61, no. 10, pp. 1367–1373, 2003. View at Google Scholar · View at Scopus
  33. P. J. Waters, A. McKeon, M. I. Leite et al., “Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays,” Neurology, vol. 78, no. 9, pp. 665–671, 2012. View at Publisher · View at Google Scholar