Clinical Study

Overall Memory Impairment Identification with Mathematical Modeling of the CVLT-II Learning Curve in Multiple Sclerosis

Figure 1

Cluster analysis of the CVLT-II measures trials 1–5. (a) Healthy male participants, cluster referring to lower memory functioning (9 cases) and cluster referring to higher memory functioning (11 cases). Comparing the values for every trial with a 𝑡 -test for independent samples revealed that the same trial values differed between cluster referring to lower memory functioning and cluster referring to higher memory functioning ( 𝑃 < . 0 5 ) with the exception of Trial 3 ( 𝑃 = . 0 7 5 ). (b) MS male patients, cluster referring to lower memory functioning (46 cases) and cluster referring to higher memory functioning (53 cases). Comparing the values for each of the five trials with a 𝑡 -test for independent samples, revealed significant differences between cluster referring to lower memory functioning and cluster referring to higher memory functioning for each trial ( 𝑃 . 0 0 1 ). (c) Healthy female participants, cluster referring to lower memory functioning (38 participants) and cluster referring to higher memory functioning (40 participants). Comparing values for every trial with a 𝑡 -test for independent samples revealed that the same trial values differed between cluster referring to lower memory functioning and cluster referring to higher memory functioning ( 𝑃 < . 0 0 1 ). (d) MS female patients, cluster referring to lower memory functioning (133 patients) and cluster referring to higher memory functioning (133 patients). Comparing values for every trial with a 𝑡 -test for independent samples revealed that the same trial values differed between cluster referring to lower memory functioning and cluster referring to higher memory functioning ( 𝑃 < . 0 0 1 ). Cluster referring to lower memory functioning—white bar, cluster referring to higher memory functioning—gray bar. Each bar represents mean ± S.E.M.
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(a) Healthy male participants
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(b) MS male patients
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(c) Healthy female participants
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(d) MS female patients