Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography

Table 3

OCT results for the subtypes of MS patients with a history of optic neuritis (ON). Total retinal nerve fiber layer (RNFL) thickness (in 𝜇m) and total macular volume (TMV in mm³) are given as mean values with standard deviation (SD). ON eyes were compared to ON-non affected eyes of the same MS subtype using generalized estimation equation (GEE) models. GEE models estimate the effect size with standard error (SE) and the respective 𝑃 value.

			GEE models comparing OCT parameters between ON-affected and unaffected eyes of the same subtype
				RNFL thickness			TMV
	Total RNFL thickness mean (SD) [𝜇m]	TMV mean (SD) [mm^3]	Effect	Effect size	SE	𝑃 value	Effect size	SE	𝑃 value
			Group	−12.199	1.336	<0.001	−0.237	0.043	<0.001
MS-ON; (𝑛=183)	77.88; (14.61)	8.24; (0.45)	Age	−0.147	0.056	0.008	−0.007	0.002	0.001
			Gender	2.989	1.161	0.010	−0.041	0.040	0.299
			Group	−12.859	1.478	<0.001	−0.263	0.048	<0.001
RRMS-ON; (𝑛=156)	78.69; (14.91)	8.28; (0.45)	Age	−0.087	0.066	0.185	−0.004	0.002	0.071
			Gender	4.573	1.352	0.001	−0.048	0.046	0.295
			Group	−9.297	2.802	0.001	−0.252	0.100	0.012
SPMS-ON; (𝑛=27)	73.19; (11.89)	8.05; (0.41)	Age	0.419	0.216	0.052	0.009	0.008	0.234
			Gender	−7.310	2.591	0.005	−0.250	0.091	0.006
PPMS-ON; (𝑛=0)	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
HC; (𝑛=183)	100.60; (9.41)	8.75; (0.34)	N/A	N/A	N/A	N/A	N/A	N/A	N/A