Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years: A Longitudinal Study

Table 4

Relationship between cortical volume and disability progression over 2 years in patients with relapsing-remitting multiple sclerosis.

Disability progression	Coefficient	Standard Error	𝑇	𝑃 value
Disease duration	0.04	0.015	2.99	0.003
CV	−0.001	0.0004	−2.57	0.01
Disease duration	0.05	0.015	3.11	0.002
WBV	−0.0003	0.0002	−1.55	0.12
Disease duration	0.05	0.015	3.11	0.002
T2-LV	0.005	0.004	1.21	0.23

CV: cortical volume, WBV: whole brain volume, and LV: lesion volume.
The statistical analysis between CV and disability progression, as measured by EDSS, was performed using mixed effect model analyses on all bi-monthly serial MRI time points of the study over 2 years.
When adjusted for baseline CV, by using the changes in CV from baseline and every six months in our analysis, the association with disability progression became nonsignificant in both early and late RRMS groups (𝑃=0.13).
The LVs are in milliliters.