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Multiple Sclerosis International
Volume 2013, Article ID 671730, 11 pages
Review Article

DTI Measurements in Multiple Sclerosis: Evaluation of Brain Damage and Clinical Implications

Department of Neurology and Psychiatry, Sapienza University, Viale dell’Università 30, 00185 Rome, Italy

Received 23 December 2012; Revised 20 February 2013; Accepted 5 March 2013

Academic Editor: Rob Bermel

Copyright © 2013 Emilia Sbardella et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded noteworthy results. DTI abnormalities, which are already detectable in patients with clinically isolated syndrome (CIS), become more pronounced as disease duration and neurological impairment increase. The assessment of the microstructural alterations of white and grey matter in MS may shed light on mechanisms responsible for irreversible disability accumulation. In this paper, we examine the DTI analysis methods, the results obtained in the various tissues of the central nervous system, and correlations with clinical features and other MRI parameters. The adoption of DTI metrics to assess the outcome of prognostic measures may represent an extremely important step forward in the MS research field.