Multiple Sclerosis International / 2013 / Article / Tab 2

Clinical Study

Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis

Table 2

(a) Fornix correlations with disability and MSFC. (b) Cingulum correlations with disability and MSFC.
(a)

Outcome variableFAMDParallel diff.Perp. diff.MTR

Disease duration −0.22 (0.03)0.26 (0.008)0.25 (0.01)0.26 (0.01) −0.17 (0.10)
EDSS −0.30 (0.003)0.29 (0.003)0.26 (0.01)0.3 (0.003) −0.18 (0.07)
-score 25FTW 0.20 (0.06) −0.17 (0.11) −0.13 (0.25) −0.20 (0.06)0.008 (0.94)
-score 9-HPT0.33 (0.002)−0.35 (0.001)−0.30 (0.005)−0.34 (0.001)0.21 (0.05)
-score PASAT-3 0.24 (0.03)−0.23 (0.04) −0.13 (0.24)−0.26 (0.02)0.24 (0.03)

(b)

Outcome variableFAMDParallel diff.Perp. diff.MTR

Average cingula
 Disease duration −0.22 (0.03)0.11 (0.28) −0.14 (0.18)0.19 (0.05) −0.05 (0.60)
 EDSS −0.20 (0.05)0.03 (0.78)−0.25 (0.01)0.17 (0.09) −0.02 (0.85)
-score 25-FTW 0.04 (0.71)0.16 (0.12)0.17 (0.10)0.05 (0.63) 0.03 (0.78)
-score 9-HPT0.22 (0.03)−0.23 (0.02)0.06 (0.55)−0.27 (0.007)0.03 (0.75)
-score PASAT-30.18 (0.08) −0.14 (0.17)0.11 (0.28) −0.17 (0.10)0.07 (0.48)
Left Cingulum
 Disease duration −0.27 (0.008)0.17 (0.09) −0.14 (0.18)0.23 (0.02) −0.09 (0.37)
 EDSS −0.25 (0.01)0.04 (0.66)−0.27 (0.006)0.22 (0.03) −0.09 (0.40)
-score 25-FTW 0.07 (0.51)0.09 (0.39)0.13 (0.21) −0.02 (0.86)0.07 (0.47)
-score 9-HPT0.28 (0.005)−0.21 (0.03)0.10 (0.34)−0.28 (0.005)0.08 (0.42)
-score PASAT-30.31 (0.002)−0.22 (0.04)0.06 (0.54)−0.29 (0.004)0.15 (0.15)
Right cingulum
 Disease duration −0.13 (0.19)0.13 (0.19) −0.07 (0.50)0.14 (0.17) −0.07 (0.47)
 EDSS −0.07 (0.49)0.03 (0.75) −0.04 (0.72)0.06 (0.53) 0.04 (0.68)
-score 25FTW 0.05 (0.60)0.15 (0.15)0.18 (0.08)0.06 (0.58)0.08 (0.46)
-score 9-HPT0.11 (0.28) −0.20 (0.05) −0.07 (0.52)−0.17 (0.08) −0.06 (0.54)
-score PASAT-30.09 (0.38) −0.08 (0.40)0.05 (0.60) −0.12 (0.22)−0.005 (0.96)

FA: fractional anisotropy, MD: mean diffusivity, : parallel diffusivity, λ : perpendicular diffusivity, MTR: magnetization transfer ratio, MSFC: multiple sclerosis functional composite, EDSS: Expanded Disability Status Scale, 25FTW: Timed 25-Foot Walk, 9-HPT: 9-Hole Peg Test, PASAT-3: Paced Auditory serial Addition Task-3, second version. Partial correlation coefficients were adjusted for additive effects of age and sex. Significance levels are shown in parenthesis. Results with are shown in boldface.