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Multiple Sclerosis International
Volume 2014 (2014), Article ID 692468, 6 pages
Research Article

Does Fatigue Complaint Reflect Memory Impairment in Multiple Sclerosis?

1Department of Neurology, Roger Salengro Hospital, 59037 Lille, France
2Department of Biostatistics and INSERM EA 2694, Lille University Hospital and University of Lille North of France, 59037 Lille, France

Received 28 November 2013; Revised 23 January 2014; Accepted 23 January 2014; Published 2 March 2014

Academic Editor: Francesco Patti

Copyright © 2014 Caroline Jougleux-Vie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Purpose. Fatigue and memory impairment are common symptoms in multiple sclerosis (MS) and both may interact with cognition. This can contribute to making a complaint misrepresentative of the objective disorder. We sought to determine whether fatigue complaint in MS reflects memory impairment and investigated whether patients’ subjective fatigue is associated with memory complaint. Methods. Fifty MS patients complaining of fatigue underwent subjective assessment of fatigue and memory complaint measured using self-assessment scales. Cognitive functions were assessed using a battery of neuropsychological tests, including a test of verbal episodic memory, the selective reminding test (SRT). Correlations were studied between subjective fatigue, memory complaint, and performance in verbal episodic memory. Results. Depression score, psychotropic and/or antiepileptic drug use, Expanded Disability Status Scale (EDSS) score, and MS form were confounding factors. After adjusting for these confounding factors, neither fatigue complaint nor memory complaint was correlated with SRT performance. Subjective fatigue was significantly associated with memory complaint. Conclusion. Although complaint of fatigue in MS was correlated with memory complaint, subjective fatigue was not the expression of memory impairment.