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Multiple Sclerosis International
Volume 2014, Article ID 732329, 4 pages
Research Article

Bedside Tested Ocular Motor Disorders in Multiple Sclerosis Patients

1Department of Medical and Health Sciences, University of Trieste, 34100 Trieste, Italy
2Service de Neurologie, Centre Hospitalier Universitaire Caremeau, 30029 Nîmes, France
3Service de Neurologie, Centre Hospitalier Universitaire Guy de Chauliac, 34090 Montpellier, France
4Service de Epidemiologie, Centre Hospitalier Universitaire Caremeau, 30029 Nîmes, France
5UCO di Neurologia, Ospedale di Cattinara, Strada di Fiume 447, 34149 Trieste, Italy

Received 21 January 2014; Revised 15 April 2014; Accepted 16 April 2014; Published 30 April 2014

Academic Editor: Bianca Weinstock-Guttman

Copyright © 2014 G. Servillo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background/Aims. Ocular motor disorders (OMDs) are a common feature of multiple sclerosis (MS). In clinical practice, if not reported by patients, OMDs are often underdiagnosed and their prevalence is underestimated. Methods. We studied 163 patients (125 women, 76.7%, 38 men, 23.3%; median age 45.0 years; median disease duration 10 years; median EDSS 3.5) with definite MS (, 92%) or clinically isolated syndrome (, 8%) who underwent a thorough clinical examination of eye movements. Data on localization of previous relapses, MS subtype, and MRI findings were collected and analyzed. Results. Overall, 111/163 (68.1%) patients showed at least one abnormality of eye movement. Most frequent OMDs were impaired smooth pursuit (42.3%), saccadic dysmetria (41.7%), unilateral internuclear ophthalmoplegia (14.7%), slowing of saccades (14.7%), skew deviation (13.5%), and gaze evoked nystagmus (13.5%). Patients with OMDs had more severe disability and showed more frequently infratentorial MRI lesions . Localization of previous relapses was not associated with presence of OMDs. Conclusion. OMDs are frequent in patients with stable (no relapses) MS. A precise bedside examination of eye motility can disclose abnormalities that imply the presence of subclinical MS lesions and may have a substantial impact on definition of the diagnosis and on management of MS patients.