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Multiple Sclerosis International
Volume 2015, Article ID 681289, 9 pages
Review Article

The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis

Department of Neuro-Ophthalmology, The National Hospital for Neurology and Neurosurgery, Box 93, Queen Square, London WC1N 3BG, UK

Received 22 September 2015; Accepted 2 December 2015

Academic Editor: Francesco Patti

Copyright © 2015 Mithu Storoni and Gordon T. Plant. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in disease progression. In this review, we explore the relationship between mitochondrial dysfunction and neurodegeneration in multiple sclerosis. We review evidence that the ketogenic diet can improve mitochondrial function and discuss the potential of the ketogenic diet in treating progressive multiple sclerosis for which no treatment currently exists.