Neuroimaging of Natalizumab Complications in Multiple Sclerosis: PML and Other Associated Entities

Figure 10

27-year-old female with a typical relapse severity prior to natalizumab of 0–2 enhancing lesions on MRI. The patient was treated with natalizumab for 30 months without clinical or radiologic relapse but ceased natalizumab due to JCV Ab conversion. 3.3 months after cessation, patient relapsed and imaging demonstrated rebound with >14 enhancing lesions.