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Multiple Sclerosis International
Volume 2015, Article ID 960282, 8 pages
Research Article

Does Self-Efficacy Affect Cognitive Performance in Persons with Clinically Isolated Syndrome and Early Relapsing Remitting Multiple Sclerosis?

1MS4 Research Institute, Ubbergseweg 34, 6522 KJ Nijmegen, Netherlands
2Department of Community & Occupational Medicine, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands
3Swinburne University, John Street, Hawthorn, Melbourne, VIC 3122, Australia
4Medisch Centrum Alkmaar, Wilhelminalaan 12, 1815 JD Alkmaar, Netherlands
5Viecuri Medisch Centrum, Merseloseweg 130, 5801 CE Venray, Netherlands
6Westfries Gasthuis, Maelsonstraat 3, 1624 NP Hoorn, Netherlands
7St. Elisabeth Ziekenhuis, Hilvarenbeekseweg 60, 5022 GC Tilburg, Netherlands
8Reinier de Graaf Gasthuis, Reinier de Graafweg 3-11, 2625 AD Delft, Netherlands
9Medisch Centrum Leeuwarden, Henri Dunantweg 2, 8934 AD Leeuwarden, Netherlands
10Department of Experimental Psychology, Utrecht University, Heidelberglaan 2, 3584 CS Utrecht, Netherlands
11Zuwe Hofpoort Ziekenhuis, Regionaal Psychiatrisch Centrum Woerden, Polanerbaan 2, 3447 GN Woerden, Netherlands

Received 8 February 2015; Accepted 15 April 2015

Academic Editor: Angelo Ghezzi

Copyright © 2015 Peter Joseph Jongen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In persons with multiple sclerosis (MS) a lowered self-efficacy negatively affects physical activities. Against this background we studied the relationship between self-efficacy and cognitive performance in the early stages of MS. Thirty-three patients with Clinically Isolated Syndrome (CIS) and early Relapsing Remitting MS (eRRMS) were assessed for self-efficacy (MSSES-18), cognition (CDR System), fatigue (MFIS-5), depressive symptoms (BDI), disease impact (MSIS-29), and disability (EDSS). Correlative analyses were performed between self-efficacy and cognitive scores, and stepwise regression analyses identified predictors of cognition and self-efficacy. Good correlations existed between total self-efficacy and Power of Attention (; ), Reaction Time Variability (; ), and Speed of Memory (; ), and between control self-efficacy and Reaction Time Variability (; ). Total self-efficacy predicted 40% of Power of Attention, 34% of Reaction Time Variability, and 40% of Speed of Memory variabilities. Disease impact predicted 65% of total self-efficacy and 58% of control self-efficacy variabilities. The findings may suggest that in persons with CIS and eRRMS self-efficacy may positively affect cognitive performance and that prevention of disease activity may preserve self-efficacy.