The Prevalence of Anti-Aquaporin 4 Antibody in Patients with Idiopathic Inflammatory Demyelinating Diseases Presented to a Tertiary Hospital in Malaysia: Presentation and Prognosis
Table 2
AQP4 positive ()
AQP4 negative ()
value
Number of M/F
4/49 (1 : 12.25)
10/37 (1 : 3.70)
Age of onset (years)
37.79 (±SD 13.064)
31.74 (±SD 12.669)
0.021
Frequency of symptoms
CMS
1/53 (1.89%)
27/47 (57.45%)
<0.001
Tumefactive
0/53 (0.00%)
1/47 (2.13%)
0.323
ON
4/53 (7.55%)
4/47 (8.51%)
0.861
TM
16/53 (30.19%)
9/47 (19.15%)
0.140
OS (ONTM)
26/53 (49.06%)
5/47 (10.64%)
<0.001
BSOS
3/53 (5.66%)
1/47 (2.13%)
0.373
Cortical, OS
1/53 (1.89%)
0/47 (0.00%)
0.349
BSTM
2/53 (3.77%)
0/47 (0.00%)
0.159
CSF OCB
Positive
7/12 (58.33%)
17/30 (56.67%)
Negative
5/12(41.67%)
13/30 (43.33%)
NA
41/53 (77.36%)
17/47 (36.17%)
LESCLs (>3VB)
26/40 (65.00%)
6/37 (16.22%)
0.025
CMJ + LESCLs
3/40 (7.50%)
1/37 (2.70%)
0.696
Total LESCLs
29/40 (72.50%)
7/37 (18.92%)
0.004
CMJ
1/40 (2.50%)
1/37 (2.70%)
0.704
Patchy, multiple short segments
2/40 (5.00%)
19/37 (51.35%)
0.003
Normal MRI spine
4/40 (10.00%)
10/37 (27.03%)
0.466
MRI spine NA
10/53 (18.87%)
13/47 (27.66%)
M = male, F = female, AQP4 = Aquaporin 4, SD = standard deviation, CMS = classical multiple sclerosis, ON = optic neuritis, TM = transverse myelitis, ONTM = optic neuritis and transverse myelitis, OS = opticospinal, BSOS = brainstem and opticospinal, BSTM = brainstem and transverse myelitis, CSF OCB = Cerebral Spinal Fluid Oligoclonal Band, NA = not available, LESCLs = longitudinally extensive spinal cord lesions, VB = vertebral body, and CMJ = cervicomedullary junction. significant with a value < 0.05.
