The Effects of Aerobic Exercise on the Recovery of Walking Ability and Neuroplasticity in People with Multiple Sclerosis: A Systematic Review of Animal and Clinical Studies

Table 2

Methodological quality assessment of the animal studies included in this review.

Articles included	SYRCLE’s risk of bias tool, scoring criteria										SYRCLE’s score
	(1)	(2)	(3)	(4)	(5)	(6)	(7)	(8)	(9)	(10)
Bernardes et al. [49]	N	Y	N	N	N	N	N	N	Y	Y	3/10
Patel and White [50]	Y	Y	N	N	N	N	N	N	Y	Y	4/10
Wens et al. [51]	Y	Y	N	N	N	N	N	Y	Y	Y	5/10
Klaren et al. [52]	Y	Y	N	N	N	N	N	N	Y	Y	4/10
Patel et al. [53]	Y	Y	N	N	N	N	N	N	Y	Y	4/10
Total score	4	5	0	0	0	0	0	0	5	5

(1) Sequence generation; (2) baseline characteristics; (3) allocation concealment; (4) random housing; (5) blinding—investigators; (6) random outcome assessment; (7) blinding—outcome assessors; (8) incomplete outcome data addressed; (9) no selective outcome reporting; (10) no other sources of bias. Y (yes) = 1; N (no) = 0; U (unclear) = 0. SYRCLE: SYstematic Review Centre for Laboratory animal Experimentation; : sum of scores; %: percentage.