|
| Gene (polymorphic locus) | Product function (if known) | Number of loci | Nature of response for each polymorphism |
|
| IFNAR1 (rs1012334; rs55884088) [41, 42] | Type I membrane protein that forms one of the two chains of a receptor for IFNα and IFNβ | 2 | +, + |
|
| LMP7 (rs2071543) [42] | Subunit of the immunoproteasome which generates peptides presented on MHC class I molecules to cytotoxic T cells | 1 | + |
|
| CTSS (rs1136774) [42] | Cathepsin S, a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules | 1 | + |
|
| MXA (rs2071430; rs17000900) [42] | An antiviral protein induced in immune system cells by type I IFNs | 2 | +, + |
|
| IRF5 (rs2004640) [43] | IFN regulatory factor 5, transcription factor involved in both type I IFN and Toll-like receptor signaling pathways | 1 | − |
|
| IRF8 (rs17445836) [44] | IFN regulatory factor 8, transcription factor of the IFN regulatory factor family | 1 | − |
|
| USP18 (rs2542109) [45] | Member of the ubiquitin-specific proteases family of enzymes that cleave ubiquitin from ubiquitinated protein substrates | 1 | + |
|
| IFNG (polymorphic microsatellites in the first intron) [46] | IFNγ | 4 | −, −, −, + |
|
| IL10 (rs1800896; rs1800871; rs1800872) [47] | Interleukin-10 | 1 | + |
|
| CCR5 (rs333) [48] | Member of the β chemokine receptor family, expressed by T cells and macrophages | 1 | + |
|
| TGFB1 (rs1800469) [48] | Member of the transforming growth factor β family of cytokines | 1 | + |
|
| TRAILR1 (rs20576) [49] | Tumor necrosis factor-related apoptosis-inducing ligand | 1 | + |
|
| CD58 (rs12044852) [50] | Ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes | 1 | − |
|
| CD46 (rs2724385) [51] | Type I membrane protein that is a regulatory part of the complement system | 1 | + |
|
| GPC5 (rs10492503; rs1411751) [52] | Cell surface heparan sulfate proteoglycan | 2 | +, + |
|
