|
| Gene (polymorphic locus) | Product function (if known) |
|
| GPC5 (rs10492503; rs9301789) [54] | Glypicans are implicated in synapse formation and axon regeneration and guidance and are found in dense networks in active MS plaques, where they may be involved in sequestering proinflammatory chemokines |
|
| COL25A1 (rs794143) [54] | Collagen type XXV α1, a brain-specific membrane-bound collagen |
|
| HPLN1 (rs4466137) [54] | Hyaluronan proteoglycan link protein 1, an extracellular matrix protein |
|
| CAST (rs10510779) [54] | Calpastatin, a calpain (calcium-dependent cysteine protease) inhibitor |
|
| NPAS3 (rs4128599) [54] | Neuronal PAS domain protein 3, a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors |
|
| GRIA3 (rs12557782) [56] | α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor component |
|
| ADAR (rs2229857) [56] | Type 1 interferon-related protein, responsible for RNA editing by site-specific deamination of adenosines |
|
| IFNAR2 (rs2248202) [56] | Interferon (α, β, and ω) receptor 2 |
|
| CIT (rs7308076) [56] | Serine/threonine-protein kinase that functions in cell division |
|
| ZFAT (rs733254) [56] | Zinc-finger protein, binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival |
|
| ZFHX4 (rs11787532) [56] | Zinc-finger protein, may play a role in neural and muscle differentiation |
|
| STARD13 (rs9527281) [56] | Guanosine triphosphatase-activating protein, may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility |
|
| SLC9A9 (rs9828519) [57] | Solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9, localized in endosomes and may play an important role in maintaining cation homeostasis |
|
| NINJ2 (rs7298096) [55] | Ninjurin 2, member of the ninjurin (for nerve injury induced) family |
|
| TBXAS1 (rs4726460) [55] | Thromboxane A synthase 1, member of the cytochrome P450 superfamily of enzymes that catalyze many reactions involved in drug metabolism |
|
| GRM3 (rs2237562) [55] | Glutamate receptor 3 |
|
| GRIK2 (rs1475919) [55] | Glutamate receptor, ionotropic, kainate 2 |
|
| FHIT (rs760316) [58] | Fragile histidine triad involved in purine metabolism |
|
| GAPVD1 (rs10819043; rs2291858; rs10760397) [58] | Guanosine triphosphatase activating protein and VPS9 domains 1, participates in various processes such as endocytosis, insulin receptor internalization, or LC2A4/GLUT4 trafficking |
|
