Review Article

State-of-the-Art Review: Demyelinating Diseases in Indonesia

Table 1

MRI protocol comparison.

MAGNIMS MR protocol recommendation [10]Standard MR protocol in our center

Brain
Baseline evaluationBaseline and follow-up examinations
 Mandatory sequences(i) Unenhanced axial and sagittal T1-weighted
 (i) Axial proton-density and/or T2-FLAIR/T2-weighted(ii) Contrast-enhanced axial, sagittal, and coronal T1-weighted
 (ii) Sagittal 2D or 3D T2-FLAIR(iii) Axial and coronal T2-weighted
 (iii) 2D or 3D contrast-enhanced T1-weighted(iv) Axial T2-FLAIR
 Optional sequences(v) Axial T2 gradient-echo (GRE)
 (i) Unenhanced 2D or high-resolution isotropic 3D T1-weighted(vi) Axial diffusion-weighted imaging
 (ii) 2D and/or 3D dual inversion recovery
 (iii) Axial diffusion-weighted imaging
Follow-up examinations
 Mandatory sequences
 (i) Axial proton-density and/or T2-FLAIR/T2-weighted highly recommended
 (ii) 2D or 3D contrast-enhanced T1-weighted
 Optional sequences
 (i) Unenhanced 2D or high-resolution isotropic 3D T1-weighted
 (ii) 2D and/or 3D dual inversion recovery
 (iii) Axial diffusion-weighted imaging

Spinal cord
Sagittal imagingSagittal imaging
 Mandatory sequences(i) Unenhanced T1-weighted
 (i) Dual-echo (proton-density and T2-weighted) conventional and/or fast spin-echo(ii) Contrast-enhanced T1-weighted with fat suppression
 (ii) STIR (as an alternative to proton-density-weighted)(iii) Conventional T2-weighted
 (iii) Contrast-enhanced T1-weighted spin-echo (if T2 lesions present)(iv) T2-weighted with turbo inversion recovery magnitude (TIRM)
 Optional sequences
 (i) Phase-sensitive inversion recovery (as an alternative to STIR at the cervical segment)
Axial imagingAxial imaging
 Optional sequences(i) Unenhanced T1-weighted
 (i) 2D and/or 3D T2-weighted fast spin-echo(ii) Contrast-enhanced T1-weighted with fat suppression
 (ii) Contrast-enhanced T1-weighted spin-echo(iii) T2-weighted with turbo inversion recovery magnitude (TIRM)