Evaluation of Month of Birth in Neuromyelitis Optica Spectrum Disorders (NMSOD) and Multiple Sclerosis (MS)

Table 3

Comparison of numbers of monthly births among different MS types.

(a)

Month	RRMS vs. control		SPMS vs. control		PPMS vs. control
	OR (95% CI)		OR (95% CI)		OR (95% CI)
March-April	1.572 (1.282-1.927)	<0.001	1.773 (1.260-2.493)	0.001	1.741 (0.895-3.385)	0.102
April-May	1.185 (0.937-1.497)	0.156	1.041 (0.660-1.641)	0.862	0.989 (0.390-2.509)	0.981
May-June	1.232 (0.981-1.547)	0.073	1.018 (0.657-1.577)	0.936	2.611 (1.391-4.903)	0.003
June-July	0.920 (0.734-1.153)	0.470	0.927 (0.612-1.402)	0.718	0.566 (0.203-1.576)	0.276
July-August	1.245 (0.986-1.571)	0.065	1.379 (0.909-2.93)	0.131	1.002 (0.395-2.541)	0.997
August-September	1.314 (1.103-1.567)	0.002	1.023 (0.734-1.424)	0.895	0.937 (0.473-1.856)	0.853
September-October	0.482 (0.378-0.614)	<0.001	0.410 (0.252-0.669)	<0.001	0.513 (0.204-1.292)	0.157
October-November	0.714 (0.534-0.954)	0.023	0.454 (0.225-0.914)	0.027	0.991 (0.352-2.786)	0.986
November-December	0.793 (0.615-1.022)	0.074	0.914 (0.566-1.476)	0.714	1.214 (0.513-2.870)	0.659
December-January	0.747 (0.585-0.955)	0.020	0.614 (0.363-1.038)	0.069	0.879 (0.347-2.226)	0.785
January-February	0.962 (0.738-1.255)	0.777	1.656 (1.074-2.552)	0.022	0.981 (0.349-2.757)	0.972
February-March	0.861 (0.676-1.095)	0.223	1.068 (0.697-1.635)	0.764	0.331 (0.080-1.366)	0.126

(b)

Month	RRMS vs. SPMS		RRMS vs. PPMS		SPMS vs. PPMS
	OR (95% CI)		OR (95% CI)		OR (95% CI)
March-April	1.134 (0.818-1.572)	0.450	1.114 (0.577-2.150)	0.747	0.982 (0.486-1.986)	0.961
April-May	0.879 (0.564-1.369)	0.568	0.835 (0.331-2.106)	0.703	0.950 (0.351-2.569)	0.920
May-June	0.819 (0.534-1.256)	0.360	2.099 (1.126-3.913)	0.020	2.563 (1.253-5.245)	0.010
June-July	1.00 (0.662-1.513)	0.998	0.611 (0.220-1.700)	0.345	0.611 (0.208-1.789)	0.369
July-August	1.113 (0.744-1.665)	0.602	0.809 (0.321-2.038)	0.652	0.726 (0.273-1.931)	0.522
August-September	0.785 (0.567-1.085)	0.143	0.720 (0.365-1.421)	0.343	0.917 (0.442-1.903)	0.817
September-October	0.845 (0.509-1.403)	0.516	1.057 (0.416-2.685)	0.908	1.250 (0.451-3.466)	0.668
October-November	0.638 (0.316-1.288)	0.210	1.393 (0.495-3.922)	0.530	2.184 (0.654-7.292)	0.204
November-December	1.145 (0.711-1.844)	0.578	1.520 (0.643-3.588)	0.340	1.327 (0.518-3.398)	0.555
December-January	0.822 (0.486-1.390)	0.464	1.176 (0.464-2.979)	0.732	1.432 (0.511-4.013)	0.495
January-February	1.739 (1.140-2.652)	0.010	1.030 (0.368-2.883)	0.955	0.593 (0.203-1.734)	0.339
February-March	1.235 (0.808-1.889)	0.329	0.382 (0.093-1.579)	0.184	0.310 (0.072-1.327)	0.114