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Neural Plasticity
Volume 7 (2000), Issue 1-2, Pages 19-29

GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory

Laboratoire de Neurociences Comportementales et Cognitives LN2C UMR7521 ULP/CNRS, 12 rue Goethe , Strasbourg 67000, France

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Reversible inactivation of brain areas is a useful method for inferring brain-behavior relationships. Infusion of GABA or of the GABA receptor agonist muscimol is considered one interesting reversible inactivation method because it may not affect fibers of passage and may therefore be compared to axon-sparing types of lesions. This article reviews the data obtained with this method in learning and memory experiments. A critical analysis of data, collected in collaboration with Simon Brailowsky, with chronic GABA infusion is presented, together with an illustration of data obtained with muscimol-induced inactivation.