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Neural Plasticity
Volume 2007 (2007), Article ID 26496, 9 pages
http://dx.doi.org/10.1155/2007/26496
Research Article

Chronic Fluoxetine Treatment Induces Brain Region-Specific Upregulation of Genes Associated with BDNF-Induced Long-Term Potentiation

Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, Bergen 5009, Norway

Received 23 March 2007; Accepted 27 July 2007

Academic Editor: Monica Di Luca

Copyright © 2007 Maria Nordheim Alme et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [58 citations]

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  • Andre Russowsky Brunoni, Mariana Lopes, and Felipe Fregni, “A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression,” International Journal Of Neuropsychopharmacology, vol. 11, no. 8, pp. 1169–1180, 2008. View at Publisher · View at Google Scholar
  • Zofia Rogóż, and Grażyna Skuza, “Effect of repeated co-treatment with fluoxetine and amantadine on the behavioral reactivity of the central dopamine and serotonin system in rats,” Pharmacological Reports, vol. 61, no. 5, pp. 924–929, 2009. View at Publisher · View at Google Scholar
  • Cristina Lanni, Stefano Govoni, Adele Lucchelli, and Cinzia Boselli, “Depression and antidepressants: Molecular and cellular aspects,” Cellular and Molecular Life Sciences, vol. 66, no. 18, pp. 2985–3008, 2009. View at Publisher · View at Google Scholar
  • Eva Biringer, Arvid Rongve, and Anders Lund, “A review of modern antidepressants' effects on neurocognitive function,” Current Psychiatry Reviews, vol. 5, no. 3, pp. 164–174, 2009. View at Publisher · View at Google Scholar
  • Smita Thakker-Varia, and Janet Alder, “Neuropeptides in depression: Role of VGF,” Behavioural Brain Research, vol. 197, no. 2, pp. 262–278, 2009. View at Publisher · View at Google Scholar
  • Lynette Hui-Wen Lee, Guanghou Shui, Akhlaq A. Farooqui, Markus R. Wenk, Chay-Hoon Tan, and Wei-Yi Ong, “Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids?,” The International Journal of Neuropsychopharmacology, vol. 12, no. 07, pp. 953, 2009. View at Publisher · View at Google Scholar
  • David Chandler, Milan Dragovic´, Matthew Cooper, Johanna C. Badcock, Benjamin H. Mullin, Deb Faulkner, Scott G. Wilson, Joachim Hallmayer, Sarah Howell, Daniel Rock, Lyle J. Palmer, Luba Kalaydjieva, and Assen Jablensky, “ Impact of Neuritin 1 ( NRN1 ) polymorphisms on fluid intelligence in schizophrenia ,” American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 9999B, 2009. View at Publisher · View at Google Scholar
  • Eun-Joo Shin, Hoon Jeong Ji, Hee Chung Yoon, Tae-Woo Kim, Young Shin Chan, Won-Ki Kim, Kwang-Ho Ko, and Hyoung-Chun Kim, “Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats: Possible involvement of an impaired synaptic transmission to the 5-HT2A receptor,” Journal of Pharmacological Sciences, vol. 110, no. 3, pp. 401–404, 2009. View at Publisher · View at Google Scholar
  • Michael W. Otto, R. Kathryn McHugh, and Kathleen M. Kantak, “Combined Pharmacotherapy and Cognitive-Behavioral Therapy for Anxiety Disorders: Medication Effects, Glucocorticoids, and Attenuated Treatment Outcomes,” Clinical Psychology: Science and Practice, vol. 17, no. 2, pp. 91–103, 2010. View at Publisher · View at Google Scholar
  • Lisa Bjartmar, Liza Alkhori, Johan Ruud, Abdul H. Mohammed, Jan Marcusson, and Martin Hallbeck, “Long-term treatment with antidepressants, but not environmental stimulation, induces expression of NP2 mRNA in hippocampus and medial habenula,” Brain Research, vol. 1328, pp. 25–33, 2010. View at Publisher · View at Google Scholar
  • Yifeng Hu, Jianjun Yang, Yuping Hu, Yu Wang, and Weiyan Li, “Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory,” European Journal of Anaesthesiology, vol. 27, no. 2, pp. 162–168, 2010. View at Publisher · View at Google Scholar
  • Chun-Chun Li, and Fang-Jen Lee, “Arf-like protein 4D,” AfCS-Nature Molecule Pages, 2010. View at Publisher · View at Google Scholar
  • Karin Wibrand, Debabrata Panja, Adrian Tiron, May L. Ofte, Kai-O. Skaftnesmo, Cherin S Lee, John T.G. Pena, Thomas Tuschl, and Clive R. Bramham, “ Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo ,” European Journal of Neuroscience, vol. 31, no. 4, pp. 636–645, 2010. View at Publisher · View at Google Scholar
  • Clive R. Bramham, Maria N. Alme, Margarethe Bittins, Sjoukje D. Kuipers, Rajeevkumar R. Nair, Balagopal Pai, Debabrata Panja, Manja Schubert, Jonathan Soule, Adrian Tiron, and Karin Wibrand, “The Arc of synaptic memory,” Experimental Brain Research, vol. 200, no. 2, pp. 125–140, 2010. View at Publisher · View at Google Scholar
  • Malayannan Subramaniam, John R. Hawse, Nalini M. Rajamannan, James N. Ingle, and Thomas C. Spelsberg, “Functional role of KLF10 in multiple disease processes,” BioFactors, vol. 36, no. 1, pp. 8–18, 2010. View at Publisher · View at Google Scholar
  • Porcelli, Drago, Fabbri, and Serretti, “Mechanisms of antidepressant action: An integrated dopaminergic perspective,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 35, no. 7, pp. 1532–1543, 2011. View at Publisher · View at Google Scholar
  • Francisco J. Monje, Eun-Jung Kim, Maureen Cabatic, Gert Lubec, Kurt R. Herkner, and Daniela D. Pollak, “A role for glucocorticoid-signaling in depression-like behavior of gastrin-releasing peptide receptor knock-out mice,” Annals of Medicine, vol. 43, no. 5, pp. 389–402, 2011. View at Publisher · View at Google Scholar
  • Laura Lyons, Maha ElBeltagy, Jariya Umka, Rachel Markwick, Carla Startin, Geoffrey Bennett, and Peter Wigmore, “Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy,” Psychopharmacology, vol. 215, no. 1, pp. 105–115, 2011. View at Publisher · View at Google Scholar
  • Olivier Deschaux, Guillaume Spennato, Jean-Luc Moreau, and René Garcia, “Chronic treatment with fluoxetine prevents the return of extinguished auditory-cued conditioned fear,” Psychopharmacology, vol. 215, no. 2, pp. 231–237, 2011. View at Publisher · View at Google Scholar
  • Yiming Wang, Zhengjun Xiao, Xingde Liu, and Michael Berk, “Venlafaxine modulates depression-induced behaviour and the expression of Bax mRNA and Bcl-xl mRNA in both hippocampus and myocardium,” Human Psychopharmacology: Clinical and Experimental, vol. 26, no. 2, pp. 95–101, 2011. View at Publisher · View at Google Scholar
  • Peilin Jia, Chung-Feng Kao, Po-Hsiu Kuo, and Zhongming Zhao, “A comprehensive network and pathway analysis of candidate genes in major depressive disorder,” BMC Systems Biology, vol. 5, no. 3, 2011. View at Publisher · View at Google Scholar
  • Caroline M. Coppens, Taweeporn Sipornmongcolchai, Karin Wibrand, Maria Nordheim Alme, Bauke Buwalda, Sietse F. de Boer, Jaap M. Koolhaas, and Clive R. Bramham, “Social defeat during adolescence and adulthood differentially induce BDNF-regulated immediate early genes,” Frontiers in Behavioral Neuroscience, no. NOVEMBER, 2011. View at Publisher · View at Google Scholar
  • Jian Xin Liu, Scarlett B. Pinnock, and Joe Herbert, “Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat,” PLoS ONE, vol. 6, no. 3, 2011. View at Publisher · View at Google Scholar
  • Karin Wibrand, Balagopal Pai, Taweeporn Siripornmongcolchai, Margarethe Bittins, Birgitte Berentsen, May Lillian Ofte, Arwed Weigel, Kai Ove Skaftnesmo, and Clive R. Bramham, “MicroRNA regulation of the synaptic plasticity-related gene Arc,” PLoS ONE, vol. 7, no. 7, 2012. View at Publisher · View at Google Scholar
  • H. Son, M. Banasr, M. Choi, S. Y. Chae, P. Licznerski, B. Lee, B. Voleti, N. Li, A. Lepack, N. M. Fournier, K. R. Lee, I. Y. Lee, J. Kim, J.-H. Kim, Y. H. Kim, S. J. Jung, and R. S. Duman, “Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress,” Proceedings of the National Academy of Sciences, vol. 109, no. 28, pp. 11378–11383, 2012. View at Publisher · View at Google Scholar
  • Elham Satvat, Ali Gheidi, Sarah Voll, Irina V. Odintsova, and Diano F. Marrone, “Location is everything: Neurons born during fluoxetine treatment accumulate in regions that do not support spatial learning,” Neuropharmacology, vol. 62, no. 4, pp. 1627–1633, 2012. View at Publisher · View at Google Scholar
  • J. Herbert, M. Ban, G. W. Brown, T. O. Harris, A. Ogilvie, R. Uher, and T. K. J. Craig, “Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women,” British Journal Of Psychiatry, vol. 201, no. 4, pp. 313–319, 2012. View at Publisher · View at Google Scholar
  • Laura Lyons, Maha ELBeltagy, Geoffrey Bennett, and Peter Wigmore, “Fluoxetine counteracts the cognitive and cellular effects of 5-Fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery,” PLoS ONE, vol. 7, no. 1, 2012. View at Publisher · View at Google Scholar
  • Björn Spittau, and Kerstin Krieglstein, “Klf10 and Klf11 as mediators of TGF-beta superfamily signaling,” Cell and Tissue Research, vol. 347, no. 1, pp. 65–72, 2012. View at Publisher · View at Google Scholar
  • Shunit Gal-Ben-Ari., and Kobi Rosenblum, “Molecular mechanisms underlying memory consolidation of taste information in the cortex,” Frontiers in Behavioral Neuroscience, no. 2012, 2012. View at Publisher · View at Google Scholar
  • Maria A. Tikhonova, Alexander V. Kulikov, Daria V. Bazovkina, Maryana V. Morozova, Vladimir S. Naumenko, and Nina K. Popova, “Antidepressant-like effects of central BDNF administration in mice of Antidepressant Sensitive Catalepsy (ASC) strain,” Chinese Journal of Physiology, vol. 55, no. 4, 2012. View at Publisher · View at Google Scholar
  • Cheng Jiang, and Stephen R. Salton, “The role of neurotrophins in major depressive disorder,” Translational Neuroscience, vol. 4, no. 1, pp. 46–58, 2013. View at Publisher · View at Google Scholar
  • Stephanie C. Licata, Nina M. Shinday, Megan N. Huizenga, Shayna B. Darnell, Gavin R. Sangrey, Uwe Rudolph, James K. Rowlett, and Ghazaleh Sadri-Vakili, “Alterations in Brain-Derived Neurotrophic Factor in the Mouse Hippocampus Following Acute but Not Repeated Benzodiazepine Treatment,” Plos One, vol. 8, no. 12, 2013. View at Publisher · View at Google Scholar
  • Mi Kyoung Seo, Chan Hong Lee, Hye Yeon Cho, Jung Goo Lee, Bong Ju Lee, Ji Eun Kim, Wongi Seol, Young Hoon Kim, and Sung Woo Park, “Effects of Antidepressant Drugs on Synaptic Protein Levels and Dendritic Outgrowth in Hippocampal Neuronal Cultures,” Neuropharmacology, 2013. View at Publisher · View at Google Scholar
  • Karin Wibrand, Kjetil Berge, Michael Messaoudi, Anais Duffaud, Debabrata Panja, Clive R. Bramham, and Lena Burri, “Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats,” Lipids In Health And Disease, vol. 12, 2013. View at Publisher · View at Google Scholar
  • Kendra K. Schmid, William J. Burke, William M. Lydiatt, Harlan Sayles, and Diane Bessette, “Prevention of Depression With Escitalopram in Patients Undergoing Treatment for Head and Neck Cancer Randomized, Double-blind, Placebo-Controlled Clinical Trial,” Jama Otolaryngology-Head & Neck Surgery, vol. 139, no. 7, pp. 678–686, 2013. View at Publisher · View at Google Scholar
  • Fuencisla Pilar-Cuéllar, Rebeca Vidal, Alvaro Díaz, Elena Castro, Severiano dos Anjos, Jesús Pascual-Brazo, Raquel Linge, Veronica Vargas, Helena Blanco, Beatriz Martínez-Villayandre, Ángel Pazos, and Elsa M. Valdizán, “Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication,” Neural Plasticity, vol. 2013, pp. 1–21, 2013. View at Publisher · View at Google Scholar
  • Jesse S. O. Lindholm, and Eero Castrén, “Mice with altered BDNF signaling as models for mood disorders and antidepressant effects,” Frontiers in Behavioral Neuroscience, vol. 8, 2014. View at Publisher · View at Google Scholar
  • Benjamin A. Samuels, E. David Leonardo, Alex Dranovsky, Amanda Williams, Erik Wong, Addie May I. Nesbitt, Richard D. McCurdy, Rene Hen, and Mark Alter, “Global State Measures of the Dentate Gyrus Gene Expression System Predict Antidepressant-Sensitive Behaviors,” Plos One, vol. 9, no. 1, 2014. View at Publisher · View at Google Scholar
  • Zhou, and Zhou, “Neuritin, a neurotrophic factor in nervous system physiology,” Current Medicinal Chemistry, vol. 21, no. 10, pp. 1212–1219, 2014. View at Publisher · View at Google Scholar
  • Hans C. Dringenberg, Leora R. Branfield Day, and Deanna H. Choi, “Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo,” Neural Plasticity, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Y. Kroeze, D. Peeters, F. Boulle, D. L. A. van den Hove, H. van Bokhoven, H. Zhou, and J. R. Homberg, “Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus,” Translational Psychiatry, vol. 5, 2015. View at Publisher · View at Google Scholar
  • S Alboni, R M van Dijk, S Poggini, G Milior, M Perrotta, T Drenth, N Brunello, D P Wolfer, C Limatola, I Amrein, F Cirulli, L Maggi, and I Branchi, “Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment,” Molecular Psychiatry, 2015. View at Publisher · View at Google Scholar
  • Kerise Lyttle, Yu Ohmura, Kohtarou Konno, Takayuki Yoshida, Takeshi Izumi, Masahiko Watanabe, and Mitsuhiro Yoshioka, “Repeated fluvoxamine treatment recovers juvenile stress-induced morphological changes and depressive-like behavior in rats,” Brain Research, vol. 1616, pp. 88–100, 2015. View at Publisher · View at Google Scholar
  • Yan Li, Alan L. Pehrson, Jessica A. Waller, Elena Dale, Connie Sanchez, and Maria Gulinello, “A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression,” Frontiers in Neuroscience, vol. 9, 2015. View at Publisher · View at Google Scholar
  • Liu Luo, Xiao-Long Liu, Rong-Hao Mu, Yong-Jing Wu, Bin-Bin Liu, Di Geng, Qing Liu, and Li-Tao Yi, “Hippocampal BDNF signaling restored with chronic asiaticoside treatment in depression-like mice,” Brain Research Bulletin, vol. 114, pp. 62–69, 2015. View at Publisher · View at Google Scholar
  • Simona Daniele, Eleonora Da Pozzo, Elisa Zappelli, and Claudia Martini, “Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-kB, p38 and JNK,” Cellular Signalling, 2015. View at Publisher · View at Google Scholar
  • Iku Tsutsui-Kimura, Takayuki Yoshida, Yu Ohmura, Takeshi Izumi, and Mitsuhiro Yoshioka, “Milnacipran Remediates Impulsive Deficits in Rats with Lesions of the Ventromedial Prefrontal Cortex,” International Journal Of Neuropsychopharmacology, vol. 18, no. 5, 2015. View at Publisher · View at Google Scholar
  • Brandon H. Cline, Joao P. Costa-Nunes, Raymond Cespuglio, Natalyia Markova, Ana I. Santos, Yury V. Bukhman, Aslan Kubatiev, Harry W. M. Steinbusch, Klaus-Peter Lesch, and Tatyana Strekalova, “Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression,” Frontiers in Behavioral Neuroscience, vol. 9, 2015. View at Publisher · View at Google Scholar
  • Yassine Bentefour, Youness Rakibi, Mohamed Bennis, Saadia Ba-M'hamed, and Rene Garcia, “Paroxetine treatment, following behavioral suppression of PTSD-like symptoms in mice, prevents relapse by activating the infralimbic cortex,” European Neuropsychopharmacology, vol. 26, no. 2, pp. 195–207, 2016. View at Publisher · View at Google Scholar
  • Jariya Umka Welbat, Preeyanuch Sangrich, Pornthip Chaisawang, Parichat Prachaney, Wanassanun Pannangrong, Peter Wigmore, Apiwat Sirichoat, and Wunnee Chaijaroonkhanarak, “Fluoxetine prevents the memory deficits and reduction in hippocampal cell proliferation caused by valproic acid,” Journal of Chemical Neuroanatomy, vol. 78, pp. 112–118, 2016. View at Publisher · View at Google Scholar
  • Huaibo Zhang, Dadasaheb M. Kokare, Amul J. Sakharkar, Ryan P. Vetreno, Fulton T. Crews, and Subhash C. Pandey, “A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood,” Brain Structure and Function, vol. 221, no. 9, pp. 4691–4703, 2016. View at Publisher · View at Google Scholar
  • Afsaneh Shirani, Darin T. Okuda, and Olaf Stueve, “Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis,” Neurotherapeutics, vol. 13, no. 1, pp. 58–69, 2016. View at Publisher · View at Google Scholar
  • M. Santoro, V. Nociti, C. De Fino, A. Caprara, R. Giordano, N. Palomba, F. Losavio, C. Marra, A. K. Patanella, M. Mirabella, G. Gainotti, and D. Quaranta, “Depression in multiple sclerosis: effect of brain derived neurotrophic factor Val66Met polymorphism and disease perception,” European Journal of Neurology, 2016. View at Publisher · View at Google Scholar
  • David A. Connor, and Thomas J. Gould, “Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning,” Neuropharmacology, 2017. View at Publisher · View at Google Scholar
  • E Castrén, and H Antila, “Neuronal plasticity and neurotrophic factors in drug responses,” Molecular Psychiatry, 2017. View at Publisher · View at Google Scholar
  • Pirathiv Kugathasan, Jessica Waller, Ligia Westrich, Aicha Abdourahman, Joseph A Tamm, Alan L Pehrson, Elena Dale, Maria Gulinello, Connie Sanchez, and Yan Li, “In vivo and in vitro effects of vortioxetine on molecules associated with neuroplasticity,” Journal of Psychopharmacology, vol. 31, no. 3, pp. 365–376, 2017. View at Publisher · View at Google Scholar
  • Prats, Arias, Ortet, Moya, Pomarol-Clotet, Ibáñez, Fañanás, and Fatjó-Vilas, “Neurotrophins role in depressive symptoms and executive function performance: Association analysis of NRN1 gene and its interaction with BDNF gene in a non-clinical sample,” Journal of Affective Disorders, vol. 211, pp. 92–98, 2017. View at Publisher · View at Google Scholar