Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo

Jang, Jinhwa; Ha, Hee-Jin; Kim, Yun Bok; Chung, Young-Ki; Jung, Min Whan

doi:https://doi.org/10.1155/2007/29821

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Research Article | Open Access

Volume 2007 | Article ID 029821 | https://doi.org/10.1155/2007/29821

Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo

Jinhwa Jang,¹Hee-Jin Ha,^1,2Yun Bok Kim,^1,3Young-Ki Chung,⁴and Min Whan Jung¹

Academic Editor: Donald A. Wilson

Received13 Apr 2007

Revised14 Jun 2007

Accepted14 Jun 2007

Published23 Aug 2007

Abstract

To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a subset of neurons transiently (<30 min) elevating their activities. The direction of firing rate change was poorly predicted by the mean firing rate or the degree of burst firing during the baseline period. Also, simultaneously recorded units showed opposite directions of firing rate change, indicating that recording location is a poor predictor of the direction of firing rate change. These results raise the possibility that systemic MA injection induces random bidirectional changes in prefrontal cortical unit activity, which may underlie some of MA-induced psychotic symptoms.

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Copyright © 2007 Jinhwa Jang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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