Neural Plasticity

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Volume 2007 |Article ID 073754 | https://doi.org/10.1155/2007/73754

Eleni Paizanis, Michel Hamon, Laurence Lanfumey, "Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy", Neural Plasticity, vol. 2007, Article ID 073754, 7 pages, 2007. https://doi.org/10.1155/2007/73754

Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy

Academic Editor: Georges Chapouthier
Received30 Nov 2006
Accepted05 Mar 2007
Published14 May 2007

Abstract

There is a growing body of evidence that neural stem cells reside in the adult central nervous system where neurogenesis occurs throughout lifespan. Neurogenesis concerns mainly two areas in the brain: the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone, where it is controlled by several trophic factors and neuroactive molecules. Neurogenesis is involved in processes such as learning and memory and accumulating evidence implicates hippocampal neurogenesis in the physiopathology of depression. We herein review experimental and clinical data demonstrating that stress and antidepressant treatments affect neurogenesis in opposite direction in rodents. In particular, the stimulation of hippocampal neurogenesis by all types of antidepressant drugs supports the view that neuroplastic phenomena are involved in the physiopathology of depression and underlie—at least partly—antidepressant therapy.

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